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Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease.
https://repo.qst.go.jp/records/46521
https://repo.qst.go.jp/records/4652171fe22c6-d8ae-4f1e-9edc-6cd16d60f9b6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-04-11 | |||||
| タイトル | ||||||
| タイトル | Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takanashi, Junichi
× Takanashi, Junichi× Saito, Shigeyoshi× Aoki, Ichio× et.al× 高梨 潤一× 齋藤 茂芳× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To evaluate the N-acetylaspartate (NAA) and N-acetylaspartylglutamate(NAAG) biochemical pathways in the brain of myelin synthesis-deficient (msd) mouse, a model of Pelizaeus-Merzbacher disease (PMD). Materials and Methods: We performed magnetic resonance imaging and proton magnetic resonance spectroscopy (1H-MRS) of the thalamus for msd and wildtype mice with a 7.0 T magnet. NAA and NAAG were independently measured by high-performance liquid chromatography (HPLC). Immunohistochemical analysis using anti-Mbp, Gfap, Ng2, and NeuN antibodies were also performed. Results: 1H-MRS in msd mice revealed increased total NAA (tNAA, NAAþNAAG), creatine, glutamine, and glutamate and decreased choline (Cho). HPLC analysis revealed increases of both NAA and NAAG in the msd brains. Histologically, the msd brains revealed hypomyelination and astrogliosis. Oligodendrocyte progenitor cells and neurons were normal in number in the thalamus wherein 1H-MRS was obtained. Conclusion: The evidence suggests that the neurochemical derangement in the msd mice may be a primary increase of NAA resulting in a secondary increase of NAAG. Increased tNAA with decreased Cho detectable on 1H-MRS may be an important marker for PMD, and might be used to distinguish it from more common neurological disorders that have decreased tNAA. |
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| 書誌情報 |
Journal of Magnetic Resonance Imaging : JMRI 巻 35, 号 2, p. 418-425, 発行日 2011-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-1807 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/jmri.22817 | |||||
