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  1. 原著論文

Radiotherapy with fraction size of 2.25 Gy in T1-2 laryngeal and hypopharyngeal cancer

https://repo.qst.go.jp/records/46510
https://repo.qst.go.jp/records/46510
6b0648dd-ce86-4bb3-9997-8d2548514998
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-03-28
タイトル
タイトル Radiotherapy with fraction size of 2.25 Gy in T1-2 laryngeal and hypopharyngeal cancer
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Karasawa, Kumiko

× Karasawa, Kumiko

WEKO 463480

Karasawa, Kumiko

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Kunogi, Hiroaki

× Kunogi, Hiroaki

WEKO 463481

Kunogi, Hiroaki

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Hirai, Takahisa

× Hirai, Takahisa

WEKO 463482

Hirai, Takahisa

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Hoji, Hidehiro

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WEKO 463483

Hoji, Hidehiro

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Hirowatari, Hisako

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WEKO 463484

Hirowatari, Hisako

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Izawa, Hiromi

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WEKO 463485

Izawa, Hiromi

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Ito, Kana

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WEKO 463486

Ito, Kana

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Sasai, Keisuke

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WEKO 463487

Sasai, Keisuke

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Furuya, Tomohisa

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WEKO 463488

Furuya, Tomohisa

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Ozawa, Shuichi

× Ozawa, Shuichi

WEKO 463489

Ozawa, Shuichi

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Matsumoto, Fumihiko

× Matsumoto, Fumihiko

WEKO 463490

Matsumoto, Fumihiko

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Ito, Shin

× Ito, Shin

WEKO 463491

Ito, Shin

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Oba, Shinichi

× Oba, Shinichi

WEKO 463492

Oba, Shinichi

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唐澤 久美子

× 唐澤 久美子

WEKO 463493

en 唐澤 久美子

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平井 崇久

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WEKO 463494

en 平井 崇久

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笹井 啓資

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WEKO 463495

en 笹井 啓資

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抄録
内容記述タイプ Abstract
内容記述 This study was carried out to evaluate the influence of fraction size 2.25 Gy on local control of T1 and T2 laryngeal and hypopharyngeal cancers. Between August 2002 and December 2010, 80 patients with T1 and T2 laryngeal or hypopharyngeal cancers were treated with definitive radiotherapy with a fraction size of 2.25 Gy. Primary sites were the larynx in 69 and the hypopharynx in 11. Fifty-three patients were
T1 and 27 were T2. All patients pathology was squamous cell carcinoma except one carcinosarcoma.
Radiotherapy was delivered 5 days/week with a 4-MV photon beam up to a total dose of 63.0 Gy. Median treatment time was 41 days. Statistical analysis of survival was calculated using the Kaplan–Meier method.
No acute toxicity greater than grade 2 (CTCAE ver. 3.0.) including mucositis and dermatitis was observed.
All but one patient had a complete response. The partial response patient received salvage surgery. The median follow-up period was 47 months (ranging from 4 to 108 months). No late toxicity greater than 1 was observed. Nine patients developed recurrence, seven local and two neck lymph nodes. Three patients died, one from laryngeal cancer and two from intercurrent diseases. The 5-year local control rates (LCRs) in the entire group, larynx T1, larynx T2 and hypopharynx T1 were 85.8%, 97.6%, 70.1% and 85.7%, respectively. The LCRs of T1 improved compared with our historical control, but not those of T2.
The 2.25-Gy fraction size is safe and may have the potential to achieve good LCR in T1 lesions.
書誌情報 Journal of Radiation Research

巻 54, 号 4, p. 684-689, 発行日 2013-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 0449-3060
DOI
識別子タイプ DOI
関連識別子 10.1093/jrr/rrs134
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