WEKO3
アイテム
Long-term adaptation of cerebral hemodynamic response to somatosensory stimulation during chronic hypoxia in awake mice
https://repo.qst.go.jp/records/46506
https://repo.qst.go.jp/records/46506805d3828-9271-4603-8efe-56c6732dbcbe
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-27 | |||||
| タイトル | ||||||
| タイトル | Long-term adaptation of cerebral hemodynamic response to somatosensory stimulation during chronic hypoxia in awake mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takuwa, Hiroyuki
× Takuwa, Hiroyuki× Masamoto, Kazuto× Yamazaki, Kyoko× Kawaguchi, Hiroshi× Ikoma, Yoko× Tajima, Yousuke× Obata, Takayuki× Kanno, Iwao× Ito, Hiroshi× et.al× 田桑 弘之× 正本 和人× 山崎 享子× 川口 拓之× 生駒 洋子× 田島 洋佑× 小畠 隆行× 菅野 巖× 伊藤 浩 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of chronic hypoxia on hemodynamic response to sensory stimulation were investigated. Using laser-Doppler flowmetry, change in cerebral blood flow (CBF) was measured in awake mice, which were housed in a hypoxic chamber (8% O2) for 1 month. The degree of increase in CBF evoked by sensory stimulation was gradually decreased over 1 month of chronic hypoxia. No significant reduction of increase in CBF induced by hypercapnia was observed during 1 month. Voltage-sensitive dye (VSD) imaging of the somatosensory cortex showed no significant decrease in neural activation over 1 month, indicating that the reduction of increase in CBF to sensory stimulation was not caused by cerebrovascular or neural dysfunction. The simulation study showed that, when effective diffusivity for oxygen in the capillary bed (D) value increases by chronic hypoxia due to an increase in capillary blood volume, an increase in the cerebral metabolic rate of oxygen utilization during neural activation can occur without any increase in CBF. Although previous study showed no direct effects of acute hypoxia on CBF response, our finding showed that hemodynamic response to neural activation could be modified in response to a change in their balance to energy demand using chronic hypoxia experiments. | |||||
| 書誌情報 |
Journal of Cerebral Blood Flow and Metabolism 巻 33, 号 5, p. 774-779, 発行日 2013-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0271-678X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/jcbfm.2013.16 | |||||
