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Predictive value of 3'-deoxy-3'-[(18)F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma.
https://repo.qst.go.jp/records/46497
https://repo.qst.go.jp/records/46497c8294236-0e36-4212-99d8-cf1c9b3c1fc1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-26 | |||||
| タイトル | ||||||
| タイトル | Predictive value of 3'-deoxy-3'-[(18)F]fluorothymidine positron emission tomography/computed tomography for outcome of carbon ion radiotherapy in patients with head and neck mucosal malignant melanoma. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inubushi, Masayuki
× Inubushi, Masayuki× Saga, Tsuneo× Koizumi, Mitsuru× Hasegawa, Azusa× Koto, Masashi× Wakatuki, Masaru× Morikawa, Takamichi× Yoshikawa, Kyosan× Tanimoto, Katsuyuki× Fukumura, Toshimitsu× Yamada, Shigeru× Kamada, Tadashi× 犬伏 正幸× 佐賀 恒夫× 小泉 満× 長谷川 安都佐× 小藤 昌志× 若月 優× 森川 貴迪× 吉川 京燦× 谷本 克之× 福村 利光× 山田 滋× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective The purpose of this prospective study was to assess the prognostic value of 30-deoxy-30-[18F]fluorothymidine (FLT) positron emission tomography/computed tomography (PET/CT) for the outcome of carbon ion radiotherapy (CIRT) in patients with mucosal malignant melanoma (MMM) of the head and neck. Methods Thirteen patients (69 +- 13 years) with histologically proven MMM tumor were enrolled. CIRT was performed with a total dose of 57.6–64.0 gray equivalents per 16 fractions over a period of 4 weeks. FLT-PET/CT was performed before and again 1 month after CIRT. Tumor FLT uptake was quantitatively assessed using the maximum standardized uptake value (SUVmax). FLT-PET parameters [pre-CIRT SUVmax, post-CIRT SUVmax, and the reduction rate (RR)] and clinical parameters [age, gender, tumor site, tumor status, gross tumor volume (GTV), and regional lymph node involvement] were evaluated in relation to survival estimates. The follow-up period was 16.1 +- 5.9 months for 9 deceased patients, and 36.7 +- 7.9 months for 4 survivors. Results Pre-CIRT SUVmax of C4.3, age of C80 years old, sinonasal cavity tumor site, and GTV of C39 mL were found to be statistically significant prognostic factors for better overall survival. Pre-CIRT SUVmax of C5.0, age of C80 years old, sinonasal cavity tumor site, and the absence of regional lymph node involvement were statistically significant prognostic factors for better metastasis-free survival. RR of C35 % and GTV of 73 mL were predictive of better local control. Conclusions The present study indicated for the first time that in patients with the head and neck MMM, FLT-PET/ CT imaging was useful for predicting the therapeutic outcome of CIRT. Our results will contribute to the establishment of an effective staging system for MMM based on prognostic factors, depending on treatment choice. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 27, 号 1, p. 1-10, 発行日 2012-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-012-0652-x | |||||
