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Carbon ion radiotherapy for localized primary sarcoma of the extremities: Results of a phase I/II trial
https://repo.qst.go.jp/records/46474
https://repo.qst.go.jp/records/46474e30d415f-63ed-4b27-a82c-5b61e9ca3b70
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-01-09 | |||||
| タイトル | ||||||
| タイトル | Carbon ion radiotherapy for localized primary sarcoma of the extremities: Results of a phase I/II trial | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sugahara, Shinji
× Sugahara, Shinji× Kamada, Tadashi× Imai, Reiko× Tsuji, Hiroshi× Kameda, Noriaki× Okada, Tohru× Tsujii, Hirohiko× Tatezaki, Shinichiroh× 菅原 信二× 鎌田 正× 今井 礼子× 辻 比呂志× 亀田 典章× 岡田 徹× 辻井 博彦× 舘崎 愼一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose To determine the effectiveness of carbon ion radiotherapy (CIRT) for localized primary sarcomas of the extremities in a prospective study. \nPatients and materials From April 2000 to May 2010, 17 (male/female: 12/5) patients with localized primary sarcoma of the extremities received CIRT. The median age was 53 years (range: 14–87 years). Nine patients had primary diseases and eight had recurrent diseases. Of the 17 patients, eight refused amputation, and the remaining nine refused surgical resection. Tumors were located in the upper limbs in four patients and lower limbs in 13. Histological diagnosis was osteosarcoma in three patients, liposarcoma in two, synovial sarcoma in two, rhabdomyosarcoma in two, pleomorphic sarcoma in two, and miscellaneous in six. The CIRT dose to the limb was 52.8 GyE for one patient, 64 GyE for three, 70.4 GyE for 13 in 16 fixed fractions over 4 weeks. Records were reviewed and outcomes including radiologic response, local control (progression-free), and survival were analyzed. \nResults The median follow-up was 37 months (range: 11–97 months). Radiological response rate was 65% (PR in 11, SD in 5, and PD in 1). The local control rate at 5 years was 76%. The overall survival rate at 5 years was 56%. Of the 17 patients, 10 survived without disease progression. Four patients had local recurrences, one was salvaged by repeated CIRT and the other three died due to systemic diseases. Distant failure was observed in six patients. One patient suffered from femoral fracture (grade 3) and received surgical fixation 27 months after CIRT. No other severe reactions (grade 3) were observed. \nConclusions CIRT is suggested to be an effective and safe treatment for patients who refuse surgery for localized primary sarcomas of the extremities |
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| 書誌情報 |
Radiotherapy and Oncology 巻 105, 号 2, p. 226-231, 発行日 2012-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.radonc.2012.09.010 | |||||
| 関連名称 | http://dx.doi.org/10.1016/j.radonc.2012.09.010 | |||||
