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  1. 原著論文

Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex

https://repo.qst.go.jp/records/46457
https://repo.qst.go.jp/records/46457
c9a2fbcf-c897-464c-bf88-af4adb2f13da
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-03
タイトル
タイトル Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Masamoto, Kazuto

× Masamoto, Kazuto

WEKO 462857

Masamoto, Kazuto

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Tomita, Yutaka

× Tomita, Yutaka

WEKO 462858

Tomita, Yutaka

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Toriumi, Haruki

× Toriumi, Haruki

WEKO 462859

Toriumi, Haruki

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Aoki, Ichio

× Aoki, Ichio

WEKO 462860

Aoki, Ichio

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Unekawa, Miyuki

× Unekawa, Miyuki

WEKO 462861

Unekawa, Miyuki

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Takuwa, Hiroyuki

× Takuwa, Hiroyuki

WEKO 462862

Takuwa, Hiroyuki

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Itoh, Yoshiaki

× Itoh, Yoshiaki

WEKO 462863

Itoh, Yoshiaki

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Suzuki, Norihiro

× Suzuki, Norihiro

WEKO 462864

Suzuki, Norihiro

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Kanno, Iwao

× Kanno, Iwao

WEKO 462865

Kanno, Iwao

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正本 和人

× 正本 和人

WEKO 462866

en 正本 和人

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冨田 裕

× 冨田 裕

WEKO 462867

en 冨田 裕

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鳥海 春樹

× 鳥海 春樹

WEKO 462868

en 鳥海 春樹

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青木 伊知男

× 青木 伊知男

WEKO 462869

en 青木 伊知男

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畝川 美悠紀

× 畝川 美悠紀

WEKO 462870

en 畝川 美悠紀

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田桑 弘之

× 田桑 弘之

WEKO 462871

en 田桑 弘之

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菅野 巖

× 菅野 巖

WEKO 462872

en 菅野 巖

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抄録
内容記述タイプ Abstract
内容記述 Understanding the cellular events evoked at the peripheral boundary of cerebral ischemia is critical for therapeutic outcome against the insult of cerebral ischemia. The present study reports a repeated longitudinal imaging for cellular-scale changes of neuro-glia-vascular unit at the boundary of cerebral ischemia in mouse cerebral cortex in vivo. Two-photon microscopy was used to trace the longitudinal changes of cortical microvasculature and astroglia following permanent middle cerebral artery occlusion (MCAO). We found that sulforhodamine 101 (SR101), a previously-known marker of astroglia, provide a bright signal in the vessels soon after the intraperitoneal injection, and that intensity was sufficient to detect the microvasculature up to a depth of 0.8 mm. After 5–8 h from the injection of SR101, cortical astroglia was also imaged up to a depth of 0.4 mm. After 1 day from MCAO, some microvessels showed a closure of the lumen space in the occluded MCA territory, leading to a restructuring of microvascular networks up to 7 days after MCAO. At the regions of the distorted microvasculature, an increase in the number of cells labeled with SR101 was detected, which was found as due to labeled neurons. Immunohistochemical results further showed that ischemia provokes neuronal uptake of SR101, which delineate a boundary between dying and surviving cells at the peripheral zone of ischemia in vivo. Finally, reproducibility of the MCAO model was evaluated with magnetic resonance imaging (MRI) in a different animal group, which showed the consistent infarct volume at the MCA territory over the subjects.
書誌情報 Neuroscience

巻 212, p. 190-200, 発行日 2012-04
ISSN
収録物識別子タイプ ISSN
収録物識別子 0306-4522
関連サイト
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1016/j.neuroscience.2012.03.034
関連名称 http://dx.doi.org/10.1016/j.neuroscience.2012.03.034
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