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Hemodynamic changes during somatosensory stimulation in awake and isoflurane-anesthetized mice measured by laser-Doppler flowmetry
https://repo.qst.go.jp/records/46389
https://repo.qst.go.jp/records/463895d23a5c5-b637-4483-b3af-69c7e753c97e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-07 | |||||
| タイトル | ||||||
| タイトル | Hemodynamic changes during somatosensory stimulation in awake and isoflurane-anesthetized mice measured by laser-Doppler flowmetry | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takuwa, Hiroyuki
× Takuwa, Hiroyuki× Matsuura, Tetsuya× Obata, Takayuki× Kawaguchi, Hiroshi× Kanno, Iwao× Ito, Hiroshi× 田桑 弘之× 松浦 哲也× 小畠 隆行× 川口 拓之× 菅野 巖× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Elucidating the mechanisms underlying the regulation of cerebral blood flow (CBF) is important to understanding the hemodynamic changes measured by positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) signals. The purpose of this study was to explore changes in hemodynamic characteristics during resting and sensory stimulation in awake animals as compared with those in anesthetized animals. Changes in CBF, red blood cell (RBC) velocity and concentration in the somatosensory cortex to whisker stimulation were measured using laser-Doppler flowmetry in awake and anesthetized mice. The increase in the rate of RBC velocity change observed during whisker stimulation was far greater than the increase in the rate of RBC concentration change under the awake condition. During the resting condition, significant differences in baseline CBF, RBC velocity and concentration between awake and anesthesia mice were not observed. Isoflurane-induced anesthesia attenuated the increase in RBC velocity and concentration during stimulation, with the attenuation of the RBC velocity increase being greater than that of RBC concentration. The RBC measurement techniques in awake animals should lead to much better understanding of the hemodynamic system evoked by neural activity. | |||||
| 書誌情報 |
Brain Research 巻 1472, p. 107-112, 発行日 2012-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-8993 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1016/j.brainres.2012.06.049 | |||||
| 関連名称 | http://dx.doi.org/10.1016/j.brainres.2012.06.049 | |||||
