ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

Triphasic low-dose response in zebrafish embryos irradiated by microbeam protons

https://repo.qst.go.jp/records/46382
https://repo.qst.go.jp/records/46382
ebc24c16-19ce-4c27-9804-9e098e4c15ff
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-08-22
タイトル
タイトル Triphasic low-dose response in zebrafish embryos irradiated by microbeam protons
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Choi, Viann

× Choi, Viann

WEKO 462053

Choi, Viann

Search repository
Konishi, Teruaki

× Konishi, Teruaki

WEKO 462054

Konishi, Teruaki

Search repository
Oikawa, Masakazu

× Oikawa, Masakazu

WEKO 462055

Oikawa, Masakazu

Search repository
H., Cheng Shuk

× H., Cheng Shuk

WEKO 462056

H., Cheng Shuk

Search repository
Yu, Peter

× Yu, Peter

WEKO 462057

Yu, Peter

Search repository
et.al

× et.al

WEKO 462058

et.al

Search repository
小西 輝昭

× 小西 輝昭

WEKO 462059

en 小西 輝昭

Search repository
及川 将一

× 及川 将一

WEKO 462060

en 及川 将一

Search repository
抄録
内容記述タイプ Abstract
内容記述 The microbeam irradiation system (Single-Particle Irradiation System to Cell, acronym as SPICE) at the National Institute of Radiological Sciences (NIRS), Japan, was employed to irradiate dechorionated zebrafish embryos at the 2-cell stage at 0.75 h post fertilization (hpf) by microbeam protons. Either one or both of the cells of the embryos were irradiated with 10, 20, 40, 50, 80, 100, 160, 200, 300 and 2000 protons each with an energy of 3.37 MeV. The embryos were then returned back to the incubator until 24 hpf for analyses. The levels of apoptosis in zebrafish embryos at 25 hpf were quantified through terminal dUTP transferase-mediated nick end-labeling (TUNEL) assay, with the apoptotic signals captured by a confocal microscope. The results revealed a triphasic dose-response for zebrafish embryos with both cells irradiated at the 2-cell stage, namely, (1) increase in apoptotic signals for <200 protons (<30 mGy), (2) hormesis to reduce the apoptotic signals below the spontaneous number for 200&#8211;500 protons (at doses of 30 75 mGy), and (3) increase in apoptotic signals again for >500 protons (at doses >75 mGy). The dose response for zebrafish embryos with only one cell irradiated at the 2-cell stage was also likely a triphasic one, but the apoptotic signals in the first zone (<200 protons or <30 mGy) did not have significant differences from those of the background. At the same time, the experimental data were in line with induction of radiation-induced bystander effect as well as rescue effect in the zebrafish embryos, particular in those embryos with unirradiated cells.
書誌情報 Journal of Radiation Research

巻 53, 号 3, p. 475-481, 発行日 2012-04
ISSN
収録物識別子タイプ ISSN
収録物識別子 0449-3060
DOI
識別子タイプ DOI
関連識別子 10.1269/jrr.11146
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 23:52:30.127805
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3