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Interleukin-9 Receptor Gene is Transcriptionally Regulated by Nucleolin in T-Cell Lymphoma Cells
https://repo.qst.go.jp/records/46368
https://repo.qst.go.jp/records/463687d8210bf-0db4-4c5c-a2b6-3320532e0823
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-07-31 | |||||
| タイトル | ||||||
| タイトル | Interleukin-9 Receptor Gene is Transcriptionally Regulated by Nucleolin in T-Cell Lymphoma Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Nishimura, Mayumi× Kobayashi, Yoshiro× Nagata, Kisaburo× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interleukin-9 (IL-9) is a multifunctional cytokine that not only has roles in immune and inflammatory responses but also is involved in growth-promoting and anti-apoptotic activities in multiple transformed cell lines, which suggests a potential role in tumorigenesis. Over-expression of the receptor of IL-9 (IL-9R) occurs in several types of human leukemias and in radiation-induced mouse T-cell lymphoma (TL). The molecular mechanism that regulates transcription of the IL-9R gene (Il9r) during leukemogenesis is, however, not well understood. Using a mouse TL cell line that has high expression of Il9r, we sought to dissect its promoter structure. Here we show that the active promoter for Il9r is located in the 5`-flanking AT-rich region. Chromatin immunoprecipitation showed the opening of chromatin structure of the promoter region coupled with nucleolin binding in vivo. Immunohistochemical analysis confirmed the increased localization of nucleolin in the nuclei of TL cells. These data indicate that increased expression of Il9r is associated with an increased binding of nucleolin, coupled with chromatin opening, to an AT-rich region in the 5'-flanking region of Il9r in TL cells. | |||||
| 書誌情報 |
Molecular Carcinogenesis 巻 51, 号 8, p. 619-627, 発行日 2012-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0899-1987 | |||||
