WEKO3
アイテム
A short-scan method for k(3) estimation with moderately reversible PET ligands: Application of irreversible model to early-phase PET data.
https://repo.qst.go.jp/records/46267
https://repo.qst.go.jp/records/46267bc7f22bf-3df9-4b52-9a7d-18ca6328465f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-02-22 | |||||
| タイトル | ||||||
| タイトル | A short-scan method for k(3) estimation with moderately reversible PET ligands: Application of irreversible model to early-phase PET data. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sato, Koichi
× Sato, Koichi× Fukushi, Kiyoshi× Shinoto, Hitoshi× Shimada, Hitoshi× Tanaka, Noriko× Hirano, Shigeki× Irie, Toshiaki× 佐藤 康一× 福士 清× 篠遠 仁× 島田 斉× 田中 典子× 平野 成樹× 入江 俊章 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Long dynamic scans (60-120min) are often required for estimating the k(3) value, an index of receptor density, by positron emission tomography (PET). However, the precision of k(3) is usually low in kinetic analyses for reversible PET ligands compared with irreversible ligands. That is largely due to unstable estimation of the dissociation rate constant, k(4). We propose a novel '3P+' method for estimating k(3) of moderately reversible ligands, where a 3-parameter model without k(4) is applied to early-phase PET data to obtain a good model-fit of k(3) estimation. By using [(11)C] Pittsburgh compound B (PIB) (k(4)=0.018/min) as an example of a moderately reversible ligand, the 3P+ method simulation with a 28min PET scan yielded less than 3% k(3) relative bias with a +100% k(3) change. In [(11)C]PIB PET scans of 15 normal controls (NC) and nine patients with Alzheimer's disease (AD), the 3P+ method provided a precise k(3) estimate (mean SE of 13.6% in parietal cortex; covariance matrix method). The results revealed linear correlations (r=0.964) of parietal k(3) values in 24 subjects between 28minute 3P+ method and conventional 90minute 4-parameter method. A good separation of k(3) between NC and AD groups (P<0.001; t-test) was replicated in 28minute 3P+ method. The short-scan 3P+ method may be a practical alternative method for analyzing reversible ligands. | |||||
| 書誌情報 |
NeuroImage 巻 59, 号 4, p. 3149-3158, 発行日 2011-11 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-8119 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.ncbi.nlm.nih.gov/pubmed/22079452 | |||||
| 関連名称 | http://www.ncbi.nlm.nih.gov/pubmed/22079452 | |||||
