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Key Role of Chemical Hardness to Compare 2,2-Diphenyl-1-picrylhydrazyl Radical Scavenging Power of Flavone and Flavonol O-Glycoside and C-Glycoside Derivatives
https://repo.qst.go.jp/records/46249
https://repo.qst.go.jp/records/462492c3a30bb-46de-46a8-92ba-c5652641dd92
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-05 | |||||
| タイトル | ||||||
| タイトル | Key Role of Chemical Hardness to Compare 2,2-Diphenyl-1-picrylhydrazyl Radical Scavenging Power of Flavone and Flavonol O-Glycoside and C-Glycoside Derivatives | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Waki, Tsukasa
× Waki, Tsukasa× Nakanishi, Ikuo× Matsumoto, Kenichiro× Kitajima, Junichi× Chikuma, Toshiyuki× Kobayashi, Shigeki× 中西 郁夫× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The antioxidant activities of flavonoids and their glycosides were measured with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The results show that free hydroxyl flavonoids are not necessarily more active than O-glycoside. Quercetin and kaempferol showed higher activity than apigenin. The C- and O-glycosides of flavonoids generally showed higher radical scavenging activity than aglyones; however, kampferol C3-O-glycoside (astragalin) showed higher activity than kaempferol. In the radical scavenging activity of flavonoids, it was expected that OH substitutions at C3 and C5 and catechol substitution at C2 of B ring and intramolecular hydrogen bonding between OH at C5 and ketone at C3 would increase the activity; however, the reasons have yet to be clarified. We here show that the radical scavenging activities of flavonoids are controlled by there absolute hardness and absolute electronegativity as an electron state must be small to increase the radical scavenging activity of flavonoids. The results show that chemically soft kaempferol and quercetin have higher DPPH radical scavenging activity than chemically hard genistein and daizein. | |||||
| 書誌情報 |
Chemical & Pharmaceutical Bulletin 巻 60, 号 1, p. 37-44, 発行日 2011-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/cpb.60.37 | |||||
