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  1. 原著論文

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

https://repo.qst.go.jp/records/46218
https://repo.qst.go.jp/records/46218
60ea7bde-246d-445e-b4dd-b51cdcfeed01
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-11-28
タイトル
タイトル The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Fischer, Eric

× Fischer, Eric

WEKO 460223

Fischer, Eric

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Scrima, Andrea

× Scrima, Andrea

WEKO 460224

Scrima, Andrea

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Bohm, Kerstin

× Bohm, Kerstin

WEKO 460225

Bohm, Kerstin

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Matsumoto, Syota

× Matsumoto, Syota

WEKO 460226

Matsumoto, Syota

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Lingaraju, Gondichatnahalli

× Lingaraju, Gondichatnahalli

WEKO 460227

Lingaraju, Gondichatnahalli

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Faty, Mahamadou

× Faty, Mahamadou

WEKO 460228

Faty, Mahamadou

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Yasuda, Takeshi

× Yasuda, Takeshi

WEKO 460229

Yasuda, Takeshi

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Cavadini, Simone

× Cavadini, Simone

WEKO 460230

Cavadini, Simone

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Wakasugi, Mitsuo

× Wakasugi, Mitsuo

WEKO 460231

Wakasugi, Mitsuo

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Hanaoka, Fumio

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WEKO 460232

Hanaoka, Fumio

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Iwai, Sigenori

× Iwai, Sigenori

WEKO 460233

Iwai, Sigenori

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Gut, Heinz

× Gut, Heinz

WEKO 460234

Gut, Heinz

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Sugasawa, Kaoru

× Sugasawa, Kaoru

WEKO 460235

Sugasawa, Kaoru

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Thoma, Nicolas

× Thoma, Nicolas

WEKO 460236

Thoma, Nicolas

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安田 武嗣

× 安田 武嗣

WEKO 460237

en 安田 武嗣

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菅澤 薫

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WEKO 460238

en 菅澤 薫

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抄録
内容記述タイプ Abstract
内容記述 The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF
DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair. We provide the molecular basis for DDB2 receptormediated cyclobutane pyrimidine dimer recognition in chromatin. The structures of the fully assembled DDB1-DDB2-CUL4A/B-RBX1 (CRL4DDB2) ligases reveal that the mobility of the ligase arm creates a defined ubiquitination zone around the damage, which precludes direct ligase activation by DNA lesions. Instead, the COP9 signalosome (CSN) mediates the CRL4DDB2 inhibition in a CSN5 independent, nonenzymatic, fashion. In turn, CSN inhibition is relieved upon DNA damage binding to the DDB2 module within CSN-CRL4DDB2. The Cockayne syndrome A DCAF complex crystal structure shows that CRL4DCAF(WD40) ligases share common architectural features. Our data support a general mechanism of ligase activation, which is induced by CSN displacement from CRL4DCAF on substrate binding to the DCAF.
書誌情報 Cell

巻 147, 号 5, p. 1024-1039, 発行日 2011-11
ISSN
収録物識別子タイプ ISSN
収録物識別子 0092-8674
DOI
識別子タイプ DOI
関連識別子 10.1016/j.cell.2011.10.035
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