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Detection of Chromosomal Instability in Bystander Cells after Si490-Ion Irradiation
https://repo.qst.go.jp/records/46187
https://repo.qst.go.jp/records/46187a160d98c-bd2d-4765-ac4b-ccb7678bbbae
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-27 | |||||
| タイトル | ||||||
| タイトル | Detection of Chromosomal Instability in Bystander Cells after Si490-Ion Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Brian, Ponnaiya
× Brian, Ponnaiya× Suzuki, Masao× Tsuruoka, Chizuru× Uchihori, Yukio× Ying, Wei× K, Hei Tom× 鈴木 雅雄× 鶴岡 千鶴× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There is increasing evidence that two of the biological effects associated with low-dose ionizing radiation, genomic instability and bystander responses, may be linked. To verify and validate the link between the two phenomena, the ability of Si490 ions (high-energy particles associated with radiation risk in space) to induce bystander responses and chromosomal instability in human bronchial epithelial (HBEC-3kt) cells was investigated. These studies were conducted at both the population and single cell level in irradiated and nonirradiated bystander cells receiving medium from the irradiated cultures. At the general population level, transfer of medium from silicon-ion (Si490)-irradiated cultures (at doses of 0.073 Gy, 1.2 Gy and 2 Gy) to nonirradiated bystander cells resulted in small increases in the levels of chromosomal aberrations at the first division. Subsequently, single cell clones isolated from irradiated and bystander populations were analyzed for the appearance of de novo chromosome-type aberrations after 50 population doublings using mFISH. Both irradiated and bystander clones demonstrated chromosomal instability (as seen by the de novo appearance of translocations and chromosomal fragments), albeit to different degrees, whereas sham-treated controls showed relatively stable chromosomal patterns. The results presented here highlight the importance of nontargeted effects of radiation on chromosomal instability in human epithelial cells and their potential relevance to human health. | |||||
| 書誌情報 |
Radiation Research 巻 176, 号 3, p. 280-290, 発行日 2011-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.rrjournal.org/doi/full/10.1667/RR2428.1 | |||||
| 関連名称 | http://www.rrjournal.org/doi/full/10.1667/RR2428.1 | |||||
