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ERK signaling controls blastema cell differentiation during planarian regeneration.
https://repo.qst.go.jp/records/46148
https://repo.qst.go.jp/records/46148e197a261-f778-469f-b407-4977d4249794
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-07-19 | |||||
| タイトル | ||||||
| タイトル | ERK signaling controls blastema cell differentiation during planarian regeneration. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tasaki, Junichi
× Tasaki, Junichi× Shibata, Norito× Nishimura, Osamu× Itomi, Kazu× Tabata, Yoshimichi× Sun, Fuyan× Suzuki, Nobuko× Araki, Ryoko× Abe, Masumi× Agata, Kiyokazu× Umesono, Yoshihiko× 田端 義巌× 孫 富艶× 鈴木 展子× 荒木 良子× 安倍 真澄× 阿形 清和 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The robust regenerative ability of planarians depends on a population of somatic stem cells called neoblasts, which are the only mitotic cells in adults and are responsible for blastema formation after amputation. The molecular mechanism underlying neoblast differentiation associated with blastema formation remains unknown. Here, using the planarian Dugesia japonica we found that DjmkpA, a planarian mitogen-activated protein kinase (MAPK) phosphatase-related gene, was specifically expressed in blastema cells in response to increased extracellular signal-related kinase (ERK) activity. Pharmacological and genetic [RNA interference (RNAi)] approaches provided evidence that ERK activity was required for blastema cells to exit the proliferative state and undergo differentiation. By contrast, DjmkpA RNAi induced an increased level of ERK activity and rescued the differentiation defect of blastema cells caused by pharmacological reduction of ERK activity. These observations suggest that ERK signaling plays an instructive role in the cell fate decisions of blastema cells regarding whether to differentiate or not, by inducing DjmkpA as a negative regulator of ERK signaling during planarian regeneration. | |||||
| 書誌情報 |
Development 巻 138, 号 12, p. 2417-2427, 発行日 2011-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0950-1991 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1242/dev.060764 | |||||
