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Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan.
https://repo.qst.go.jp/records/46140
https://repo.qst.go.jp/records/4614041bd78a4-3a80-4896-b6a7-895630f0dc50
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-07-14 | |||||
| タイトル | ||||||
| タイトル | Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okamoto, Kazushi
× Okamoto, Kazushi× Kobashi, Gen× Washio, Masakazu× Sasaki, Satoshi× Yokoyama, Tetsuji× Miyake, Yoshihiro× Sakamoto, Naomasa× Inaba, Yutaka× Nagai, Masaki× et.al× 小橋 元 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: We examined the associations between lifestyle factors and the risk of amyotrophic lateral sclerosis (ALS) using a case-control study in Aichi Prefecture, Japan. \nMETHODS: The study comprised 183 ALS patients diagnosed by the El Escorial World Federation of Neurology criteria as well as 366 gender- and age-matched controls randomly selected from the general population with the use of the basic register of residents. Detailed information on lifestyle factors was obtained through a mailed self-administered questionnaire. The strength of association between ALS and a potential risk factor was assessed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). \nRESULTS: Vigorous physical activity, self reported stress, a type A behavior pattern, and less frequent intakes of green-yellow vegetables were significantly associated with increased risk of ALS, whereas smoking and drinking habits were not. The greatest effect on risk for ALS was posed by the combination of a type A behavior pattern and less frequent intakes of green-yellow vegetables (adjusted OR, 11.2; 95% CI, 3.8 to 33.0). \nCONCLUSION: These data suggested that imbalances between excessive productions of oxidants as patient-specific factors and a diminished or missing antioxidant defense system in motor neurons may increase the risk of ALS. |
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| 書誌情報 |
Annals of Epidemiology 巻 19, 号 6, p. 359-364, 発行日 2009-06 |
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| 出版者 | ||||||
| 出版者 | http://www.sciencedirect.com/science/journal/10472797 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1047-2797 | |||||
