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Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice
https://repo.qst.go.jp/records/46107
https://repo.qst.go.jp/records/4610724749473-5d69-4638-80fe-2507f1397e70
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-14 | |||||
| タイトル | ||||||
| タイトル | Effects of calorie restriction on the age-dependent accumulation of mutations in the small intestine of lacZ-transgenic mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
He, Dongwei
× He, Dongwei× Uehara, Yoshihiko× Furuya, Maiko× Ikehata, Hironobu× Komura, Jun-ichiro× Yamauchi, Kazumi× Kakinuma, Shizuko× Shang, Yi× Shimada, Yoshiya× Ootsuyama, Akira× Norimura, Toshiyuki× Ono, Tetsuya× 山内 一己× 柿沼 志津子× 尚 奕× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To understand the effect of calorie restriction on genome maintenance systems, the age-dependent accumulation of mutations in animals maintained on high and low calorie diets was examined using lacZ-transgenic mice. Mice were fed a diet of 95 kcal/w or 65 kcal/w from 2 to 17 months of age. The mutation frequencies in the lacZ gene in epithelial tissues from the small intestine were examined at 12 and 17 months. Mutation frequencies were found to be lower in mice fed with a low calorie diet than in mice fed with a high calorie diet at the two age points. The molecular nature of the mutations was examined with DNA sequencing. It showed a predominance of transversions from G:C to T:A, and this is a typical type ofmutation induced by reactive oxygen species. The fraction of this type of mutation among the different types of mutations detected was not affected by calorie restriction. The percentage of the other types of mutation was not influenced either. These results suggest that calorie restriction reduces the age-dependent accumulation of mutations by stimulating or inducing various types of DNA protection and repair systems rather than protecting cells against any specific type of DNA alteration. | |||||
| 書誌情報 |
Mechanisms of Ageing and Development 巻 132, 号 3, p. 117-122, 発行日 2011-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0047-6374 | |||||
