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Optimization algorithm for overlapping-field plans of scanned ion beam therapy with reduced sensitivity to range and setup uncertainties
https://repo.qst.go.jp/records/46081
https://repo.qst.go.jp/records/46081c871b16f-66b6-40cb-9137-74e0e6191465
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-28 | |||||
| タイトル | ||||||
| タイトル | Optimization algorithm for overlapping-field plans of scanned ion beam therapy with reduced sensitivity to range and setup uncertainties | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inaniwa, Taku
× Inaniwa, Taku× Kanematsu, Nobuyuki× Furukawa, Takuji× Noda, Kouji× 稲庭 拓× 兼松 伸幸× 古川 卓司× 野田 耕司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A 'patch-field' strategy is often used for tumors with large volumes exceeding the available field size in passive irradiations with ion beams. Range and setup errors can cause hot and cold spots at the field junction within the target. Such errors will also displace the field to miss the target periphery. With scanned ion beams with fluence modulation, the two junctional fields can be overlapped rather than patched, which may potentially reduce the sensitivity to these uncertainties. In this study, we have developed such a robust optimization algorithm. This algorithm is composed of the following two steps: (1) expanding the target volume with margins against the uncertainties, and (2) solving the inverse problem where the terms suppressing the dose gradient of individual fields are added into the objective function. The validity of this algorithm is demonstrated through simulation studies for two extreme cases of two fields with unidirectional and opposing geometries and for a prostatecancer case. With the proposed algorithm, we can obtain a more robust plan with minimized influence of range and setup uncertainties than the conventional plan. Compared to conventional optimization, the calculation time for the robust optimization increased by a factor of approximately 3. |
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| 書誌情報 |
Physics in Medicine and Biology 巻 56, 号 6, p. 1653-1669, 発行日 2011-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0031-9155/56/6/009 | |||||
