WEKO3
アイテム
Transcription factor-recognition sequences potentially involved in modulation of gene expression after exposure to low-dose-rate gamma-rays in the mouse liver.
https://repo.qst.go.jp/records/46067
https://repo.qst.go.jp/records/4606715091382-e7ec-4b2c-a7d2-f06430ec0680
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | Transcription factor-recognition sequences potentially involved in modulation of gene expression after exposure to low-dose-rate gamma-rays in the mouse liver. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Vares, Guillaume
× Vares, Guillaume× Uehara, Yosihiko× Ono, Tetsuya× Nakajima, Tetsuo× Bing, Wang× Taki, Keiko× Matsumoto, Tsuneya× Oghiso, Yoichi× Tanaka, Kimio× Ichinohe, Kazuaki× Nakamura, Shingo× Tanaka, Satoshi× Nenoi, Mitsuru× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 上原 芳彦× 中島 徹夫× 王 冰× 瀧 景子× 松本 恒弥× 一戸 一晃× 中村 慎吾× 田中 聡× 根井 充 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Transcription factor/Low-dose-rate radiation/Microarray. In vivo modulation of gene expression profiles after low-dose and low-dose-rate irradiation has been observed in a variety of experimental systems. However, few studies actually investigated the underlying mechanisms for these genetic responses. In this study, we used pre-existing microarray data and searched for gene modulations in response to long-term, low-dose-rate irradiation. Nucleotide sequences in the neighboring region of the up-regulated, down-regulated, and unaffected genes were retrieved from the Entrez Gene database, and recognition sequences for transcription factors (TFs) were searched using the TFSEARCH database. As a result, we suggested 21 potential TF-binding sites with significantly different incidence between the three gene groups (up-regulated, down-regulated and unaffected gene groups). The binding sites for sterol regulatory element-binding protein 1 (SREBP-1), aryl hydrocarbon receptor (AhR/Ar) and olfactory 1 (Olf-1) were suggested to be involved in up-regulation, while the binding sites for glucocorticoid receptor (GR(GGTACAANNT GTYCTK) ) and hepatocyte nuclear factor 1 (HNF-1) were suggested to be involved in down-regulation of the genes. In addition, the binding sites for activating enhancer-binding protein 4 (AP-4), nuclear factor-kappa B (NFkappa B), GR (NNNNNNCNNTNTGTNCTNN) and early growth response 3 (Egr-3) were correlated with modulation of gene expression regardless of the direction of modulation. Our results suggest that these TF-binding sites are involved in gene modulations after long-term continuous irradiation with low-dose-rate gamma rays. GR and/or SREBP-1 might be associated with the altered metabolic process observed in liver after exposure to low-dose-rate irradiation. INTRODUCTION Liver is one of the target organs for radiation carcinogenesis as revealed in the follow-up studies of atomic bomb survivors in Hiroshima |
|||||
| 書誌情報 |
Journal of Radiation Research 巻 52, 号 2, p. 249-256, 発行日 2011-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1269/jrr.10110 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jstage.jst.go.jp/article/jrr/52/2/249/_pdf/-char/ja/ | |||||
| 関連名称 | http://www.jstage.jst.go.jp/article/jrr/52/2/249/_pdf/-char/ja/ | |||||
