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How are proliferation and differentiation of melanocytes regulated?
https://repo.qst.go.jp/records/46052
https://repo.qst.go.jp/records/460520fdac067-6ee0-40f4-b6b1-3364186ad6ff
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | How are proliferation and differentiation of melanocytes regulated? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The skin color and coat color are determined by melanin (eumelanin and pheomelanin). Melanin is synthesized in melanocytes and accumulated in melanosomes. Mature melanosomes are transferred to keratinocytes and the skin color and coat color are determined. Melanocytes differentiate from melanoblasts, undifferentiated precursors, derived from neural crest cells. We have been studying the mechanism of regulation of proliferation and differentiation of mouse melanocytes. Regulation by the tissue environment, especially by keratinocytes is indispensable for the regulation of melanocyte proliferation and differentiation. We have suggested that endothelins, steel factor, hepatocyte growth factor, leukemia inhibitory factor, and granulocyte-macrophage colony-stimulating factor are the keratinocyte-derived factors and regulate the proliferation and differentiation of mouse epidermal melanocytes. Moreover, a-melanocyte stimulating hormone secreted from intermediate lobe of the pituitary and sex hormones secreted from sex organs are stimulators of final differentiation of mouse melanocytes. On the other hand, numerous coat color genes are involved in regulating the expression of coat color in mice. These coat color genes regulate the proliferation and differentiation of melanocytes by controlling the proliferative rate, melanosome formation and maturation, melanosome distribution, melanosome transfer, and switch from eumelanin to pheomelanin synthesis. The expression of keratinocyte-derived melanocyte mitogens and melanogens is also regulated by the genes. The regulation of gene expression, protein expression, and activity of proteins is important for melanocyte proliferation and differentiation. | |||||
| 書誌情報 |
Pigment Cell & Melanoma Research 巻 24, 号 3, p. 462-478, 発行日 2011-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1755-1471 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1755-148x.2011.00845.x | |||||
