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Role of the Nfo and ExoA Apurinic/Apyrimidinic Endonucleases in Radiaiton Resistance and Radiation-Induced Mutagenesis of Bacillus subtilis Spores
https://repo.qst.go.jp/records/46039
https://repo.qst.go.jp/records/46039f673a81b-dbe7-4479-ab59-6b0f4cb7497d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-16 | |||||
| タイトル | ||||||
| タイトル | Role of the Nfo and ExoA Apurinic/Apyrimidinic Endonucleases in Radiaiton Resistance and Radiation-Induced Mutagenesis of Bacillus subtilis Spores | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moeller, Ralf
× Moeller, Ralf× Setlow, Peter× Pedraza-Reyes, Mario× Okayasu, Ryuichi× Reitz, Gunther× L, Nicholson Wayne× Ｍｏｅｌｌｅｒ Ｒａｌｆ× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The roles of DNA repair by apurinic/apyrimidinic (AP) endonucleases alone, and together with DNA protection by alpha/beta type small acid-soluble spore proteins (SASP), in Bacillus subtilis spore resistance to different types of radiation have been studied. Spores lacking both AP endonucleases (Nfo and ExoA) and major SASP were significantly more sensitive to 254-nm UV-C, environmental UV (>280 nm), X-ray exposure, and highenergy charged (HZE)-particle bombardment and had elevated mutation frequencies compared to those of wild-type spores and spores lacking only one or both AP endonucleases or major SASP. These findings further implicate AP endonucleases and alpha/beta type SASP in repair and protection, respectively, of spore DNA against effects of UV and ionizing radiation. |
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| 書誌情報 |
Journal of Bacteriology 巻 193, 号 11, p. 2875-2879, 発行日 2011-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021-9193 | |||||
