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Acceleration of Regeneration of Mucosa in Small Intestine Damaged by Ionizing Radiation using Anabolic Steroids.
https://repo.qst.go.jp/records/46034
https://repo.qst.go.jp/records/46034e71c05fd-0790-4f83-a422-d61b475c2be9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-04-26 | |||||
| タイトル | ||||||
| タイトル | Acceleration of Regeneration of Mucosa in Small Intestine Damaged by Ionizing Radiation using Anabolic Steroids. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishihara, Hiroshi
× Ishihara, Hiroshi× Tanaka, Izumi× Yakumaru, Haruko× Tanaka, Mika× Sato, Akiko× Ishiwata, Akiko× Yokochi, Kazuko× Kurematsu, Ayako× Ueda, Junichi× Sibata, Tomohiro× Hachiya, Misao× Akashi, Makoto× 石原 弘× 田中 泉× 薬丸 晴子× 田中 美香× 佐藤 明子× 石渡 明子× 横地 和子× 槫松 文子× 上田 順市× 柴田 知容× 蜂谷 みさを× 明石 真言 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Damage to intestine is a serious problem after accidental radiation. To examine substances to ameliorate damage by post-irradiation administration, we focused on the regeneration process following irradiation to intestine. Using experimental systems to examine the regeneration, effects of clinically used sex hormones were compared. An anabolic steroid, nandrolone (19-nortestosterone), stimulated proliferation in IEC-6 epithelial cells. Single injection of 19-nortestosterone ester with prolonged action to mice 24 h after abdominal irradiation at lethal dose of 15.7Gy showed significant life-saving effect. Regeneration indicators as microcolonies of BrdU-incorporated cells at Day 5 and c-myb mRNA expression levels at Day 4 were enhanced by 19-nortestosterone administration. In contrast, high concentration of estradiol inhibited growth of IEC-6. Introduction of estradiol ester to abdominally irradiated mice decreased levels of regeneration indicators and survival rate. These results suggest the effectiveness of anabolic steroid as well as the importance of manipulation of steroid receptors in the recovery of mucosa damaged by radiation. | |||||
| 書誌情報 |
Radiation Research 巻 175, 号 3, p. 367-374, 発行日 2011-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
