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Uptake of CDDP-containing Polymeric Micelle by Cells Using Particle Induced X-ray Emission
https://repo.qst.go.jp/records/46017
https://repo.qst.go.jp/records/46017441b3a26-6759-49dc-9d1f-f39b606bd393
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-19 | |||||
| タイトル | ||||||
| タイトル | Uptake of CDDP-containing Polymeric Micelle by Cells Using Particle Induced X-ray Emission | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mizuno, Kazue
× Mizuno, Kazue× Konishi, Teruaki× Oikawa, Masakazu× Iso, Hiroyuki× Ishikawa, Takahiro× Imaseki, Hitoshi× Uesaka, Mitsuru× 小西 輝昭× 及川 将一× 磯 浩之× 石川 剛弘× 今関 等 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Polymeric micelles loading cis-diamminedichloroplatinum(II), CDDP, (cisplatin micelle) has performed higher accumulation in solid tumors and lower toxicities compared to CDDP alone. The combinatorial use of the cisplatin micelle with radiation is expected to enhance the therapeutic effects and to reduce the side effects. The kinetics of the cisplatin micelle, however, has not been fully understood. Particle Induced X-ray Emission (PIXE) has been employed in this study to measure the time transient of platinum in Chinese Hamster Ovary (CHO) cells. The results showed that the platinum content of the cells treated with cisplatin micelle was increased slower than CDDP, suggesting that the cellular uptake could be controlled by the micelle. The released CDDP from micelles were dominantly incorporated into the cells by diffusion. The uptake characteristics were analyzed further by using the micelles with different collapse rates. These results and techniques used in this study will be useful for designing an optimum treatment plan for the combination of platinum-containing polymeric micelles and radiation toward clinical application. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 52, 号 2, p. 193-198, 発行日 2010-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1269/jrr.10074 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jstage.jst.go.jp/article/jrr/52/2/52_193/_article | |||||
| 関連名称 | http://www.jstage.jst.go.jp/article/jrr/52/2/52_193/_article | |||||
