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In Vivo and In Vitro Imaging of I2 Imidazoline Receptors in the Monkey brain.
https://repo.qst.go.jp/records/46016
https://repo.qst.go.jp/records/4601699bcdaf1-1938-4063-be60-de604343e097
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-15 | |||||
| タイトル | ||||||
| タイトル | In Vivo and In Vitro Imaging of I2 Imidazoline Receptors in the Monkey brain. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawamura, Kazunori
× Kawamura, Kazunori× Maeda, Jun× Hatori, Akiko× Okauchi, Takashi× Nagai, Yuji× Higuchi, Makoto× Suhara, Tetsuya× Fukumura, Toshimitsu× Zhang, Ming-Rong× 河村 和紀× 前田 純× 羽鳥 晶子× 岡内 隆× 永井 裕司× 樋口 真人× 須原 哲也× 福村 利光× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | I2 imidazoline receptors (I2Rs) are associated with depression, Alzheimer's disease, and Huntington's disease. However, in vivo imaging of I2Rs in the monkey brain has not been reported until now. We performed in vitro and in vivo imaging of (I2Rs) in the monkey brain using 11C-labeled 2-(3-fluoro-4-tolyl)-4,5-dihydro-1H-imidazole ([11C]FTIMD) which has high and selective affinity of I2Rs. In an auto-radiography (ARG) study, the distribution pattern of [11C]FTIMD in the monkey brain was similar to that of [3H]idazoxan binging to I2Rs in the human brain, which was previously described. The specific binding of [11C]FTIMD accounted for >97% of total binding in brain regions existing I2Rs. In positron emission tomography (PET) studies, the radioactivity was accumulated in brain regions existing I2Rs ligand BU224, the accumulated radioactivity was decreased to approximately 66%–75% of the baseline measurement at 15–45 min after injection of [11C]FTIMD. These results suggest that [11C]FTIMD shows the specific-binging to I2Rs in the monkey brain as depicted by PET and ARG. We performed the first in vivo imaging of I2Rs using [11C]FTIMD in the monkey brain. Synapse, 2011. © 2010 Wiley-Liss, Inc. | |||||
| 書誌情報 |
Synapse 巻 65, 号 5, p. 452-455, 発行日 2010-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0887-4476 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/syn.20897 | |||||
