WEKO3
アイテム
An open cohort study of bone metastasis incidence following surgery in breast cancer patients
https://repo.qst.go.jp/records/46011
https://repo.qst.go.jp/records/460119d4a4f2f-7e1a-4359-9491-0262a01c097e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-01 | |||||
| タイトル | ||||||
| タイトル | An open cohort study of bone metastasis incidence following surgery in breast cancer patients | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koizumi, Mitsuru
× Koizumi, Mitsuru× Yoshimoto, Masataka× Kasumi, Fujio× Iwase, Takuji× 小泉 満 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone metastasis was investigated in a cohort of patients. We have tried to draw the criteria to use adjuvant bisphosphonate. Methods: Consecutive breast cancer patients undergoing surgery between 1988 and 1998 (5459 patients) were followed up regarding bone metastasis until December 2006. Patients characteristics at the time of surgery were analyzed by Cox method, with bone metastasis as events. Patient groups were assigned according to Cox analysis, and were judged either to require the adjuvant bisphosphonate or not, using the tentative criteria: high risk (>3% person-year), medium risk (1-3%), and low risk (<1%). Results: Bone metastasis incidence was constant between 1.0 and 2.8% per person-year more than 10 years. Noninvasive cancer was associated with a very low incidence of bone metastasis (1/436). Multivariate Cox analysis indicated important factors for bone metastasis were tumor grade (T), nodal grade (pN), and histology. Because T and pN were important factors for bone metastasis prediction, subgroups were made by pTNM stage. Patients at stages IIIA, IIIB and IV had an incidence of >3% per person-year, patients with stage I <1% per person-year, and those with stages II were between 1 and 3%. Further analysis with histology in stage II patients showed that stage IIB with high risk histology also had a high incidence (3% person year), whereas stage IIA with medium risk histology were <1%. Conclusions: Bone metastasis incidence remained constant for many years. Using pN, T, and histopathology, patients could be classified into high, medium, and low risk groups. |
|||||
| 書誌情報 |
BMC Cancer (Online only:URL:http://www.biomedcentral.com/bmccancer) 巻 10, 号 381, p. 1-8, 発行日 2010-07 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1471-2407 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/1471-2407-10-381 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.biomedcentral.com/1471-2407/10/381 | |||||
| 関連名称 | http://www.biomedcentral.com/1471-2407/10/381 | |||||
