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Functional oestrogen receptor a imaging in endometrial carcinoma using 16a-[18F]fluoro-17b-oestradiol PET
https://repo.qst.go.jp/records/46001
https://repo.qst.go.jp/records/46001fe7d9bd7-9c45-4c31-8cdb-c59779611d72
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-02-21 | |||||
| タイトル | ||||||
| タイトル | Functional oestrogen receptor a imaging in endometrial carcinoma using 16a-[18F]fluoro-17b-oestradiol PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujibayashi, Yasuhisa
× Fujibayashi, Yasuhisa× et.al× 藤林 康久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose To investigate the correlation between uptake of 16a-[18F]fluoro-17b-oestradiol (FES) and expression of oestrogen receptors as well as other related immunohistochemistry markers, positron emission tomography (PET) was performed in patients with endometrial carcinoma before surgery. Methods Nineteen patients with endometrioid adenocarcinoma underwent preoperative PET studies with FES and 2-[18F]fluoro-2-deoxy-D-glucose (FDG). Standardized uptake values (SUVs) for each tracer and the regional FDG to FES SUV ratio were calculated using images after coregistration. PET values were compared with postoperative stage, differentiation grade and immunohistochemical scores including oestrogen receptor subtypes (ERa, ERb), progesterone receptor B (PR-B), Ki-67 and glucose transporter 1 (GLUT1). Results FES uptake showed a significantly positive correlation with expression of ERa. The FDG to FES ratio showed a significantly negative correlation with expression of ERa and PR-B. The FES uptake and FDG to FES ratio did not correlate with expression of ERb, Ki-67 or GLUT1. FDG uptake was not correlated with any of the immunohistochemical scores. The PR-B score was strongly correlated with the ERa score. Well-differentiated carcinoma (grade 1) showed a significantly higher FES uptake and significantly lower FDG to FES ratio than moderately or poorly differentiated carcinoma (grade 2–3). None of the PET parameters were significantly different between advanced-stage carcinoma (≥ stage IB) and early-stage carcinoma (IA) based on the Féderation International de Gynécologie et d'Obstétrique (FIGO) staging classification. Differentiation grade was the most closely correlated parameter to FES uptake and FDG to FES ratio by multivariate analyses. Conclusion FES PET combined with FDG would be useful for non-invasive evaluation of ERa distribution, as well as ERa function, which reflects differentiation grade in endometrial carcinoma. |
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| 書誌情報 |
European Journal of Nuclear Medicine and Molecular Imaging 巻 38, 号 1, p. 37-45, 発行日 2010-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1619-7070 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00259-010-1589-8 | |||||
