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Effect of an ATM Kinase Inhibitor on Themol- and /or Radio-sensitization in Non-proliferating Normal Human Fibroblasts and Osteosarcoma Cells
https://repo.qst.go.jp/records/45960
https://repo.qst.go.jp/records/45960d6dbca07-0ff2-4f64-99de-87432195b99b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-08 | |||||
| タイトル | ||||||
| タイトル | Effect of an ATM Kinase Inhibitor on Themol- and /or Radio-sensitization in Non-proliferating Normal Human Fibroblasts and Osteosarcoma Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inoue, Kohei
× Inoue, Kohei× Kawata, Tetsuya× Saitou, Masayoshi× Liu, CuiHua× Uno, Takashi× Isobe, Kouichi× Ito, Hisao× 井上 幸平× 川田 哲也× 斉藤 正好× 劉 翠華× 宇野 隆× 伊東 久夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This aim of the work described here was to determine the effect of an ataxia-telangiectasia mutated protein (ATM) kinase inhibitor on thermo- and/or radio-sensitivity in normal human fibroblasts cells and in osteosarcoma cells in the plateau or confluent phase of cell growth. Cell survival and chromosome aberrations were observed when cells were exposed to a heat shock at 45 degrees C and/or r-rays in the presence or absence of an ATM kinase inhibitor. Cell survival was measured with colony formation assays. Chromosome aberrations were observed using chemically induced premature chromosome condensation and fluorescence in situ hybridization. Cellular radiosensitivity was enhanced in both cell lines by a heat shock treatment at 45 degrees C. Adding an ATM kinase inhibitor amplified this effect. Furthermore, thermosensitivity in both cell lines at 45 degrees C was enhanced by treatment with an ATM kinase inhibitor. Heat shock treatments at 45 degrees C enhanced the frequency of chromosome aberrations induced by r-irradiation in both cell lines; in the presence of an ATM kinase inhibitor, the frequency of chromosome aberrations was enhanced. Thus, ATM kinase inhibitors increased the number of heat-induced aberrations. These results were observed in both,normal human fibroblasts cells and osteosarcoma cells. ATM kinase inhibitors can contribute to heat-induced cell killing and to heat-induced cellular chromosome aberration frequencies in the plateau or confluent phase of cell growth. | |||||
| 書誌情報 |
Thermal Medicine (Japanese Journal of Hyperthermic Oncology) 巻 26, 号 3, p. 97-107, 発行日 2010-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0911-2529 | |||||
