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Contribution of nitric oxide to cerebral blood flow regulation under hypoxia in rats.
https://repo.qst.go.jp/records/45948
https://repo.qst.go.jp/records/459485be21ab4-bb81-4044-bed0-3a052482bd6b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-01 | |||||
| タイトル | ||||||
| タイトル | Contribution of nitric oxide to cerebral blood flow regulation under hypoxia in rats. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takuwa, Hiroyuki
× Takuwa, Hiroyuki× Matsuura, Tetsuya× Bakalova-Zheleva, Rumiana× Obata, Takayuki× Kanno, Iwao× 田桑 弘之× 松浦 哲也× バカロバ ルミアナ× 小畠 隆行× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study was designed to clarify whether nitric oxide (NO) participates in the regulation of local cerebral blood flow (CBF) during hypoxia (inhalation of 15% O(2) in N(2)). The CBF response to hind-paw stimulation (evoked CBF) of Sprague-Dawley (SD) rats was measured by laser-Doppler flowmetry. Physiological variables, such as heart rate, mean blood pressure, and PaCO(2) during hypoxia, were identical to those under normoxic conditions. Hypoxia increased the baseline CBF (17.5 +-14.3%) and the normalized peak amplitude of evoked CBF (31.1 +-18.5%) relative to those during normoxia. When an NOS inhibitor was infused intravenously, these differences were abolished in both the baseline CBF or evoked CBF between normoxic and hypoxic conditions, whereas the heart rate decreased and the mean blood pressure increased during hypoxia in comparison with these during normoxia. The field potential was constant under all experimental conditions. These results suggest that NO plays a major role in the regulation of baseline and evoked CBF during hypoxia. | |||||
| 書誌情報 |
The Journal of Physiological Sciences 巻 60, 号 6, p. 399-406, 発行日 2010-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1880-6546 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12576-010-0108-9 | |||||
