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Potent 2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Activity of Novel Antioxidants, Double-Stranded Tyrosine Residues Conjugating Pyrocatechol
https://repo.qst.go.jp/records/45941
https://repo.qst.go.jp/records/459410ec36f28-fa59-46b2-a7bf-be8294518fda
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-11-09 | |||||
| タイトル | ||||||
| タイトル | Potent 2,2-Diphenyl-1-picrylhydrazyl Radical-Scavenging Activity of Novel Antioxidants, Double-Stranded Tyrosine Residues Conjugating Pyrocatechol | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kobayashi, Shigeki
× Kobayashi, Shigeki× Waki, Tsukasa× Nakanishi, Ikuo× Matsumoto, Kenichiro× Anzai, Kazunori× 中西 郁夫× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | New potent antioxidants conjugating the catechol (=pyrocatechol; pyrCat) group to two N-termini of modified double-stranded tyrosine residues were synthesized and showed radical-scavenging activity with 2,2-diphenyl-1-picrylhydrazyl radical (DPPH radical) as a free radical model, second-order rate constants for the DPPH radical-scavenging reaction, and the results from electron spin resonance (ESR) studies. It was found that the tyrosine (Tyr) residue and pyrCat containing new antioxidants developed in the study have about 3-20 times more potent antioxidative activity than Trolox, pyrCat, and L-ascorbic acid (VC). In order to elucidate the relationship between antioxidative activity and the molecular orbital states, and to design potent antioxidants we present an interesting approach using an absolute hardness-absolute electronegativity diagram based on chemical hardness. It was shown that quantum chemicals were required to develop potent antioxidants. | |||||
| 書誌情報 |
Chemical & Pharmaceutical Bulletin 巻 58, 号 11, p. 1442-1446, 発行日 2010-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.jstage.jst.go.jp/article/cpb/58/11/58_1442/_article | |||||
| 関連名称 | http://www.jstage.jst.go.jp/article/cpb/58/11/58_1442/_article | |||||
