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A Study on the Prognostic Evaluation of carbon ion radiotherapy for Head and Neck adenocarcinoma with C-11 Methionine PET
https://repo.qst.go.jp/records/45918
https://repo.qst.go.jp/records/4591875dce82e-2bbe-4ba9-9938-bc526903a601
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-11-01 | |||||
| タイトル | ||||||
| タイトル | A Study on the Prognostic Evaluation of carbon ion radiotherapy for Head and Neck adenocarcinoma with C-11 Methionine PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasebe, Mitsuhiko
× Hasebe, Mitsuhiko× Yoshikawa, Kyosan× Ohashi, Seiya× Toubaru, Sachiko× Kawaguchi, Koji× Satou, Junichi× Mizoe, Junetsu× Tsujii, Hirohiko× 長谷部 充彦× 吉川 京燦× 大橋 靖也× 桃原 幸子× 溝江 純悦× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L: -methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patients with adenocarcinoma in the head and neck egion. METHODS: Twenty-six patients were prospectively studied by MET-positron emission tomography (PET) before and about 1 month after CIRT. The tumor MET uptake was measured with the semiquantitative tumor to normal tissue ratio (TNR). The tumor TNR and relevant clinical parameters were then evaluated by both univariate and multivariate analyses. RESULTS: The average TNRs before and after the treatment were 6.2 (+/-2.2) and 3.9 (+/-1.7), respectively, and significant differences were observed between them. In a univariate analysis, both local recurrence and metastasis were observed more frequently in the group with a higher TNR before and after the treatment than a lower TNR, and the prognosis was also poor. The cut-off values were 9.3, 4.9, and 5.1 before the treatment and 4.9, 4.2, and 4.3 after the treatment, respectively. In the rate of TNR changes before and after the treatment, metastasis was observed more frequently in the group with lower rates of change, and the prognosis was poor. The cut-off values for metastasis and prognosis determination were 18.0% and 16.9%, respectively. In a multivariate analysis, significant differences were observed for all relationships except for the relationship between the TNR before the treatment and local recurrence. Significant differences were observed for metastasis and prognosis in the rate of TNR changes before and after the treatment. CONCLUSIONS: The determination of treatment effectiveness using TNR in CIRT for head and neck adenocarcinoma is an independent factor for predicting local recurrence, the incidence of metastasis, and the prognosis. MET-PET is therefore considered to be useful for determining the treatment effectiveness in patients with head and neck adenocarcinoma undergoing CIRT. |
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| 書誌情報 |
Molecular Imaging and Biology 巻 12, 号 5, p. 554-562, 発行日 2010-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1536-1632 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11307-010-0318-9 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.springerlink.com/content/bpj74h715003j81h/ | |||||
| 関連名称 | http://www.springerlink.com/content/bpj74h715003j81h/ | |||||
