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Regional heterogeneity and age-related change in sub-regions of internal capsule evaluated by diffusion tensor imaging
https://repo.qst.go.jp/records/45913
https://repo.qst.go.jp/records/45913ff5bc7f4-4e03-40fa-a1e8-38bcddf718d9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-25 | |||||
| タイトル | ||||||
| タイトル | Regional heterogeneity and age-related change in sub-regions of internal capsule evaluated by diffusion tensor imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawaguchi, Hiroshi
× Kawaguchi, Hiroshi× Obata, Takayuki× Ota, Miho× Akine, Yoshihide× Ito, Hiroshi× Ikehira, Hiroo× Kanno, Iwao× Suhara, Tetsuya× 川口 拓之× 小畠 隆行× 太田 深秀× 秋根 良英× 伊藤 浩× 池平 博夫× 菅野 巖× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The internal capsule (IC) includes various fiber tracts supporting sensory, motor and cognitive abilities. Diffusion tensor imaging (DTI) is useful for the diagnosis of brain diseases related to IC. However, there is some risk of misdiagnosis when measuring diffusion parameters throughout the whole IC without knowledge of age-related changes, as the thin structure and branching in multiple directions must be expected to produce sub-regional differences. In this study, regional heterogeneity and age-related changes in water diffusion parameters were evaluated in sub-regions of IC. The IC region-of-interest (ROI) was first thinned to reduce contamination from surrounding tissues and then morphologically divided into three regions: anterior limb (AL), genu and posterior limb (PL). To address the branching of PL, a procedure was applied to divide the thinned PL ROI into 10 equally-spaced positions. Estimates of fractional anisotropy (FA), mean diffusivity (MD), and longitudinal (lambda(L)) and transversal (lambda(T)) eigenvalues showed age-related and location-dependent variation in AL, genu and PL ROIs and at the 10 equally-spaced positions of PL. Simultaneous decrease of lambda(L) and increase of lambda(T) resulting in decrease of FA and steady MD with aging were observed. This might be caused by age-related atrophy of main fibers such as the pyramidal tract, possibly resulting in an increase in the relative signal contribution of some crossing fibers in each pixel. Evaluation using eigenvalues (lambda(L) and lambda(T)), as well as FA and MD, may provide important information towards understanding age-related changes and may also be useful for clinical diagnosis of diseased IC. | |||||
| 書誌情報 |
Brain Research 巻 1354, p. 30-39, 発行日 2010-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-8993 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.brainres.2010.07.084 | |||||
