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Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow
https://repo.qst.go.jp/records/45911
https://repo.qst.go.jp/records/45911b04b4393-a193-4651-9e80-7dcc15efe5d8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-21 | |||||
| タイトル | ||||||
| タイトル | Vascular Homeostasis Regulators, Edn1 and Agpt2, are Upregulated as a Protective Effect of Heat-treated Zinc Yeast in Irradiated Murine Bone Marrow | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueno, Megumi
× Ueno, Megumi× Imadome, Kaori× Iwakawa, Mayumi× Anzai, Kazunori× Ikota, Nobuo× Imai, Takashi× 上野 恵美× 今留 香織× 岩川 眞由美× 安西 和紀× 伊古田 暢夫× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To elucidate the mechanism underlying the in vivo radioprotection activity by Zn-containing, heat-treated Saccharomyces cerevisiae yeast (Zn-yeast). Materials and Methods: Zn-yeast suspension was administered into C3H/He mice immediately after WBI at 7.5 Gy. Bone marrow was extracted from the mice 6 hours after irradiation and analyzed on a microarray. Expression changes in the candidate responsive genes differentially expressed in treated mice were re-examined by qRT-PCR. The bone marrow was also examined pathologically at 6 h, 3, 7, and 14 days postirradiation. Results: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice. The expressions of Cdkn1a, Bax, and Ccng, which are well known as radioresponsive genes, were upregulated in WBI mice and Zn-yeast treated WBI mice. Pathological examination showed the newly formed microvessels lined with endothelial cells, and small round hematopoietic cells around vessels in bone marrow matrix of mice administered with Zn-yeast after WBI, while whole-body irradiated mice developed fatty bone marrow within 2 weeks after irradiation. Conclusion: This study identified a possible mechanism for the postirradiation protection conferred by Zn-yeast. The protective effect of Zn-yeast against WBI is related to maintaining the bone marrow microenvironment, including targeting endothelial cells and cytokine release. |
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| 書誌情報 |
Journal of Radiation Research 巻 51, 号 5, p. 519-525, 発行日 2010-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
