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Induction of heme oxygenase-1 by whisky congeners in human endothelial cells.
https://repo.qst.go.jp/records/45903
https://repo.qst.go.jp/records/45903c8646de5-35b2-405e-b596-71cc147da1c4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-17 | |||||
| タイトル | ||||||
| タイトル | Induction of heme oxygenase-1 by whisky congeners in human endothelial cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Keiko
× Suzuki, Keiko× Nemoto, Asuka× Tanaka, Izumi× Koshimizu, Seiichi× Suwa, Yoshihide× Ishihara, Hiroshi× 鈴木 桂子× 田中 泉× 石原 弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is expected that the production of the cytoprotective heme oxygenase-1 (HO-1) protein in endothelial cells would reduce severity of vascular injuries, while phenolic compounds are known to induce HO-1 mRNA and protein in various cells. We investigated the activation of HO-1 by whisky, which contains various phenolic substances. The congeners of whisky stored from 4 to 18 y in oak barrels were shown to induce an increase of HO-1 protein in human umbilical vein endothelial cells, while those of freshly distilled whisky spirit exhibited no activity. To determine the compounds with potent HO-1-inducing activity among the whisky congeners, several chemicals that had been reported to exist in whisky or oak barrels were screened, and coniferyl aldehyde and sinapyl aldehyde showed the activity. Thus, compounds that emerged in whisky during barrel storage induced cytoprotective protein, HO-1, in human endothelial cells. | |||||
| 書誌情報 |
Journal of Food Science 巻 75, 号 6, p. H163-H166, 発行日 2010-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-1147 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1750-3841-2010.01697.x | |||||
