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Identification of mouse mutant cells exhibiting the plastic mutant phenotype
https://repo.qst.go.jp/records/45901
https://repo.qst.go.jp/records/4590121540949-eba2-4d55-8fbf-4ef4c6b4595b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-01 | |||||
| タイトル | ||||||
| タイトル | Identification of mouse mutant cells exhibiting the plastic mutant phenotype | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamauchi, Masatake
× Yamauchi, Masatake× Fukutsu, Kumiko× Sakagami, Mari× Yamada, Yuji× 山内 正剛× 福津 久美子× 坂上 万里× 山田 裕司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The initial processes involved in radiation carcinogenesis have not been clearly elucidated. We isolated mouse mutant cells exhibiting plasticity in their mutation phenotypes. These mutant cells were originally isolated from an irradiated cell population as 6-thioguanine resistant (6TGR) mutants that were deficient in hypoxanthine phosphoribosyl transferase (Hprt, E.C.2.4.2.8) activity at the frequency of approximately 6.2 x 10-5. Approximately 10 % of 6TGR cells showed plasticity in their mutant phenotypes and reverted to HAT-resistant (HATR), that is Hprt-proficient, wild type phenotype. Eventually we identified the plastic mutants in the un-irradiated wild type cell population as well and found that ionizing irradiation enhanced the frequency of the plastic mutation approximately 24 times. Treatment with 5-aza-cytidine did not affect the plasticity of mutant phenotypes identified in this study, suggesting that DNA methylation was not involved in the plastic changes of the mutant phenotypes. The plastic mutant phenotype identified in our study is a new type of genomic instability induced by ionizing irradiation, and it is likely to be involved in one of the primary changes that occur in the process of radiation carcinogenesis, and may explain one element of carcinogenesis, which is composed of multi-stages. | |||||
| 書誌情報 |
Bioscience Trends 巻 4, 号 4, p. 195-200, 発行日 2010-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1881-7815 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.biosciencetrends.com/wholeissue.php | |||||
| 関連名称 | http://www.biosciencetrends.com/wholeissue.php | |||||
