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Distribution of Hydrogen Peroxide-dependent Reaction in a Gelatin Sample Irradiated by Carbon Ion Beam
https://repo.qst.go.jp/records/45898
https://repo.qst.go.jp/records/45898a61db4e1-9413-4f4b-a2f1-afa747185fc2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-27 | |||||
| タイトル | ||||||
| タイトル | Distribution of Hydrogen Peroxide-dependent Reaction in a Gelatin Sample Irradiated by Carbon Ion Beam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Aoki, Ichio× Nakanishi, Ikuo× Matsumoto, Atsuko× Nyui, Minako× Endo, Kazutoyo× Anzai, Kazunori× Kenichiro, Matsumoto× Ichio, Aoki× Ikuo, Nakanishi× Atsuko, Matsumoto× Minako, Nyui× Kazunori, Anzai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated the amount and distribution of hydrogen peroxide (H2O2) generated in a solid gelatin sample irradiated by heavy ion (carbon) beam. We irradiated the gelatin sample, which contained a nitroxyl radical (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, TEMPOL), with a 290-MeV/nucleon carbon beam (~128 Gy). To verify the distribution of H2O2 generation in the irradiated sample, we employed both electron paramagnetic resonance (EPR) spectroscopic and magnetic resonance (MR) imaging methods based on H2O2-dependent paramagnetic loss of TEMPOL. We obtained a distribution profile of the H2O2-dependent reaction in the gelatin sample when we irradiated gelatin samples with carbon beams with several different linear energy transfer (LET) values. Because the profiles of oxygen consumption in the gelatin sample measured by L-band EPR oxymetry and of the H2O2-dependent reaction have almost the same shape, the profile of the H2O2-dependent reaction can be used as an estimation of the profile of the generation of H2O2. The H2O2 profile in one intact gelatin sample scanned by 7-tesla MR imaging showed a similar shape as a result of the EPR experiment. We obtained several hundreds of micromolars of H2O2 generated in a gelatin sample irradiated by carbon beam when 200 Gy was given at the surface of the sample. H2O2 distribution was almost flat, with only a slight peak just before the end of the beam. | |||||
| 書誌情報 |
Magnetic Resonance in Medical Sciences 巻 9, 号 3, p. 131-140, 発行日 2010-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-3182 | |||||
