X-Rays-Induced Radioresistance against High-LET Radiations from Accelerated Heavy Ions in Mice

Induction of adaptive response (AR) by priming X-rays in combination with
challenging irradiations from high LET accelerated heavy ions (HI) was
attempted in young adult female mice of C57BL/6J Jms strain using 30-day
survival after challenging irradiations as an index. Three kinds of
accelerated HI from mono beams of carbon, silicon and iron with the LET
values of about 15, 55, and 200 keV/micrometer respectively were examined. A
priming low dose of X-rays at 0.50 Gy in combination with a challenging dose
of 7.50 Gy was used in the animals serving as a positive control group to
verify the successful induction of adaptive response. The priming low dose
of X-rays at 0.50 Gy was further used in combination with accelerated HI.
The priming low dose of X-rays significantly reduced the mortality from the
high challenging dose of carbon or silicon particles, but not from iron
particles. Results indicate that AR could be induced by priming low LET
X-rays in combination with subsequent challenging high LET irradiations from
certain kinds of accelerated heavy ions, and successful induction of AR
would be possible an event relating to the LET value or/and the HI particle
of the challenging irradiations. This is the first time to demonstrate the
existence of AR induced by low LET X-rays against high LET irradiations at
the whole body level in a mouse model. These findings would provide a new
insight into the study on radiation-induced AR in vivo.

書誌情報

Radiation Research

巻 174, 号 4, p. 532-536, 発行日 2010-07

ISSN

収録物識別子タイプ

ISSN

収録物識別子

0033-7587

DOI

識別子タイプ

DOI

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2023-05-15 23:58:18.439826

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