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Estrogen increases hair pigmentation in female recessive yellow mice.
https://repo.qst.go.jp/records/45805
https://repo.qst.go.jp/records/45805ca1ec3ea-968b-42e7-9837-858f342bb60a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-06-16 | |||||
| タイトル | ||||||
| タイトル | Estrogen increases hair pigmentation in female recessive yellow mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Kiuchi, Megumi× Wakamatsu, Kazumasa× Ito, Shosuke× 廣部 知久× 木内 めぐみ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Murine recessive yellow (Mc1re) is a loss-of-function mutation in the receptor for a-melanocyte-stimulating hormone, melanocortin receptor 1 (Mc1r), and results in a yellow coat by inducing pheomelanin synthesis in hair follicular melanocytes. We previously showed that eumelanin and pheomelanin content in dorsal hair in female Mc1re/Mc1re mice 5 weeks after birth was greater than that in male mice. To better understand the sex difference in hair pigmentation, estrogen, progesterone, and androgen were injected subcutaneously to newborn mice, and the effects of these sex hormones on hair pigmentation at 8.5 days were investigated. Although these sex hormones failed to affect the ratio of pheomelanic to eumelanic hair, they increased total hair pigmentation. Chemical analyses showed that total melanin content was increased by a low dose of estrogen in female mice. Moreover, estrogen increased pheomelanin content in female hair, whereas the hormone greatly decreased both eumelanin and pheomelanin content in male hair. High doses of progesterone, in contrast, increased total melanin content in both female and male hair. Moreover, a high dose of androgen increased total melanin content exclusively in male hair. These results suggest that estrogen is the main factor in determining the higher content of eumelanin and pheomelanin in female hair of Mc1re/Mc1re mice. | |||||
| 書誌情報 |
Zoological Science 巻 27, 号 6, p. 470-476, 発行日 2010-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0289-0003 | |||||
