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Organization of the marmoset cerebellum in three-dimensional space: lobulation, aldolase C compartmentalization and axonal projection
https://repo.qst.go.jp/records/45774
https://repo.qst.go.jp/records/4577426a09475-d8c4-443f-9113-7e3715f0167f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-26 | |||||
| タイトル | ||||||
| タイトル | Organization of the marmoset cerebellum in three-dimensional space: lobulation, aldolase C compartmentalization and axonal projection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Hirofumi
× Fujita, Hirofumi× Oh-Nishi, Arata× Obayashi, Shigeru× et.al× 大西 新× 大林 茂 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The cerebellar cortex is organized by transverse foliation and longitudinal compartmentalization. Although the latter, which is recognized through the molecular expression in subsets of Purkinje cells (PCs), is closely related to topographic axonal projection and represents functional divisions, the details have not been fully clarified in mammals other than rodents. Therefore, we examined folial and compartmental organization of the marmoset cerebellum, which resembles the macaque cerebellum, and compared it with that of the rodent cerebellum by aldolase C immunostaining, three-dimensional reconstruction of the PC layer, and labeling of olivocerebellar and corticonuclear projections. Longitudinal stripes of different aldolase C expression intensities separated the entire cerebellar cortex into multiple compartments. Lobule VIIAb-d was equivalent to rodent lobule VIc in that it contained a transverse gap in the cortical layers and served as the rostrocaudal boundary for compartments and axonal branching. Olivocortical and corticonuclear projection patterns in major compartments indicated that the compartmental organization in the marmoset cerebellum was generally equivalent to that in the rodent cerebellum, although two compartments were missing in the pars intermedia and several compartments that have not been seen in rodents were recognized in the flocculus, nodulus, and the most lateral hemisphere. Reconstruction showed that the paraflocculus and flocculus were formed by a single longitudinal sheet, the axis of which was parallel to the aldolase C compartments, PC dendrites, and olivocerebellar climbing fiber distribution. The results indicate that molecular compartmentalization in the marmoset cerebellum reflected both the common fundamental organization of the mammalian cerebellum and species-dependent differentiation. | |||||
| 書誌情報 |
The Journal of Comparative Neurology 巻 518, 号 10, p. 1764-1791, 発行日 2010-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021-9967 | |||||
