WEKO3
アイテム
Imaging of Peripheral-type Benzodiazepine Receptor in Tumor:Carbon Ion Irradiation Reduced the Uptake of a Positron Emission Tomography Ligand [11C]DAC in Tumor
https://repo.qst.go.jp/records/45763
https://repo.qst.go.jp/records/45763d88ef050-7abd-4ab3-9c04-444bf9899eba
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-03 | |||||
| タイトル | ||||||
| タイトル | Imaging of Peripheral-type Benzodiazepine Receptor in Tumor:Carbon Ion Irradiation Reduced the Uptake of a Positron Emission Tomography Ligand [11C]DAC in Tumor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamasaki, Tomoteru
× Yamasaki, Tomoteru× Koike, Sachiko× Hatori, Akiko× Yanamoto, Kazuhiko× Kawamura, Kazunori× Yui, Joji× Kumata, Katsushi× Ando, Koichi× Zhang, Ming-Rong× 山崎 友照× 小池 幸子× 羽鳥 晶子× 柳本 和彦× 河村 和紀× 由井 譲二× 熊田 勝志× 張 明栄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We aimed to determine the effect of carbon ion irradiation on the uptake of N-benzyl-N-11C-methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC), a positron emission tomography (PET) ligand for the peripheral-type benzodiazepine receptor (PBR), in tumor cells and tumor-bearing mice. Spontaneous murine fibrosarcoma (NFSa) cells were implanted into the right hind legs of syngeneic C3H male mice. Conditioning irradiation with 290 MeV/u carbon ions was delivered to the 7- to 8-mm tumors In vitro uptake of [11C]DAC was measured in single NFSa cells isolated from NFSa-bearing mice after irradiation. In vivo biodistribution of [11C]DAC in NFSa-bearing mice was determined by small animal PET scanning and dissection. In vitro autoradiography was performed using tumor sections prepared from mice after PET scanning. In vitro and in vivo uptake of [11C]DAC in single NFSa cells and NFSa-bearing mice was significantly reduced by carbon ion irradiation. The decrease in [11C]DAC uptake in the tumor sections was mainly due to the change in PBR expression. In conclusion, [11C]DAC PET responded to the change in PBR expression in tumors caused by carbon ion irradiation in this study. Thus, [11C]DAC is a promising predictor for evaluating the effect of carbon ion radiotherapy. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 51, 号 1, p. 57-65, 発行日 2010-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
