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Radiosynthesis of Novel Carbon-11-Labeled Triaryl Ligands for Cannabinoid-type 2 Receptor
https://repo.qst.go.jp/records/45762
https://repo.qst.go.jp/records/45762e1b5be3b-35ec-425a-951f-f24e8ced170d
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-03 | |||||
| タイトル | ||||||
| タイトル | Radiosynthesis of Novel Carbon-11-Labeled Triaryl Ligands for Cannabinoid-type 2 Receptor | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujinaga, Masayuki
× Fujinaga, Masayuki× Kumata, Katsushi× Yanamoto, Kazuhiko× Kawamura, Kazunori× Yamasaki, Tomoteru× Yui, Joji× Hatori, Akiko× Ogawa, Masanao× Yoshida, Yuichiro× Nengaki, Nobuki× Maeda, Jun× Zhang, Ming-Rong× 藤永 雅之× 熊田 勝志× 柳本 和彦× 河村 和紀× 山崎 友照× 由井 譲二× 羽鳥 晶子× 小川 政直× 吉田 勇一郎× 念垣 信樹× 前田 純× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Two novel triaryl ligands 2 and 5 with potent in vitro binding affinities for the cannabinoid subtype-2 (CB2) receptor were labeled with a positron-emitting radioactive nuclide 11C. Radioligands [11C]2, [11C]5, and their analogs [11C]3 and [11C]4 were synthesized by O-[11C]methylation of their corresponding phenol precursors with [11C]CH3I. [11C]2–5 had relatively high uptakes (>1.2% injected dose/g tissue) in mouse brains. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 20, 号 5, p. 1565-1568, 発行日 2010-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
