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Radiosynthesis of 13N-labeled thalidomide using no-carrier-added [13N]NH3
https://repo.qst.go.jp/records/45761
https://repo.qst.go.jp/records/45761b07207aa-785d-4fd0-bb61-521150b6e3e1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-03 | |||||
| タイトル | ||||||
| タイトル | Radiosynthesis of 13N-labeled thalidomide using no-carrier-added [13N]NH3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kumata, Katsushi
× Kumata, Katsushi× Takei, Makoto× Yui, Jyouji× Ogawa, Masanao× Hatori, Akiko× Suzuki, Kazutoshi× Zhang, Ming-Rong× 熊田 勝志× 武井 誠× 由井 譲二× 小川 政直× 羽鳥 晶子× 鈴木 和年× 張 明栄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent studies revealed that thalidomide (1) has unique and broad pharmacological effects on multi-targets although the application of 1 in therapy is still controversial. In this study, we synthesized nitrogen-13-labeled thalidomide ([13N]1) as a potential positron emission tomography (PET) probe using no-carrier-added [13N]NH3 as a labeling agent. By use of an automated system, [13N]1 was prepared by reacting N-phthaloylglutamic anhydride (2) with [13N]NH3, following by cyclization with carbonyldiimidazole in a radiochemical yield of 56712% (based on [11N]NH3, corrected for decay) and specific activity of 49724 GBq/mmol at the end of synthesis (EOS). At EOS, 570–780MBq (n=7) of [13N]1 was obtained at a beam current of 15 mA after 15 min proton bombardment with a synthesis time of 14 min from the end of bombardment. Using a small animal PET scanner, preliminary biodistribution of [13N]1 in mice was examined |
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| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 53, 号 2, p. 53-57, 発行日 2010-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
