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アイテム
p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin
https://repo.qst.go.jp/records/45682
https://repo.qst.go.jp/records/456823c4ff916-2e79-49e4-bf48-180099e4d81c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-12-11 | |||||
| タイトル | ||||||
| タイトル | p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujii, Yoshihiro
× Fujii, Yoshihiro× Kato, Takamitsu× Kubota, Nobuo× Fujimori, Akira× Niwa, Ohtsura× Okayasu, Ryuichi× 藤井 義大× 加藤 宝光× 窪田 宜夫× 藤森 亮× 丹羽 太貫× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Inhibition of heat shock protein 90 (Hsp90) is an attractive modality for cancer therapy. Recent studies presented that an Hsp90 inhibitor, 17AAG (17-Allylamino-17-demethoxygeldanamycin), enhanced tumor radio-sensitivity, while this was not observed in normal cells. One of these studies reported that the effect of this drug was only observed in tumor cells carrying the wild type p53 gene, thus demonstrating the p53 dependent tumor radiosensitization by 17AAG.. We have now tested the effects of 17AAG on two human lymphoblastoid cell lines from the same donor, TK6 cells with the wild type p53 gene and WTK1 cells with the mutated p53 gene. The effects of 17AAG were tested at concentrations of 10nM and 100nM on various parameters, including growth inhibition of the cells, enhancement of radiosensitivity by colony formation assay, apoptosis and chromosomal radiosensitivity, and abrogation of radiation induced G2/M checkpoint. When 100nM 17AAG was applied, all of these parameters were enhanced in a similar fashion in both cell lines, indicating that the drug effect is p53 independent. Our results suggest that 17AAG is likely to be an effective sensitizer for radiotherapy, even on tumors with mutated p53 | |||||
| 書誌情報 |
Oncology Reports 巻 23, 号 1, p. 199-203, 発行日 2010-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1021-335X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/or_00000623 | |||||
