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Application of monochromatic keV X-ray source to X-ray drug delivery system
https://repo.qst.go.jp/records/45681
https://repo.qst.go.jp/records/45681c9a3c9c2-5ea0-4fe6-95e8-50dfa112dd3b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-12-11 | |||||
| タイトル | ||||||
| タイトル | Application of monochromatic keV X-ray source to X-ray drug delivery system | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Uesaka, Mitsuru
× Uesaka, Mitsuru× Taguchi, Hiroki× Mori, Azusa× Yusa, Noritaka× Kato, Takamitsu× Okayasu, Ryuichi× 上坂 充× 森 梓× 加藤 宝光× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | X-ray Drug Delivery System (DDS) enhances accumulation of anti-cancer drug or contrast agent by surrounding it with polymer and Enhanced Penetration and Retention (EPR) effect. DDS uses advanced nano-scaled polymers that contain and deliver drug or contrast agent to cancers without side effects. Several X-ray DDSs pose high-Z atoms such as gold to absorb X-rays effectively and used as contrast agent for inspection. Moreover, they have radiation enhancement effect by emission of Auger electron and successive characteristic X-rays. The enhancement factor of gold is more than five. This could be used even for therapy. This new modality must be very important for inspection and therapy of deep cancers. We are making use of our X-band Compton scattering monochromatic keV X-ray source for the inspection. Numerical simulation on monochromatic X-ray CT for possible concentration of gold-colloid DDS considering the X-ray property from the source was done. Enough visibility was confirmed. Furthermore, in vitro experiment analyzed its toxic effect to cells by the Alkaline comet assay and fluorescent immunostaining method for single and double strand breaks of DNA. Availability of clear imaging for the inspection has been confirmed by the numerical simulation and the in-vitro evaluation of the therapy effect is under way. (C) 2009 Elsevier B.V. All rights reserved. | |||||
| 書誌情報 |
Nuclear Instruments & Methods in Physics Research Section A 巻 608, 号 1, p. S47-S50, 発行日 2009-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0168-9002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10,1016/j.nima,2009,05,191 | |||||
