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Activation of Antioxidative Enzymes Induced by Low-Dose-Rate Whole-Body Gamma Irradiation: Adaptive Response in Terms of Initial DNA Damage
https://repo.qst.go.jp/records/45659
https://repo.qst.go.jp/records/45659043e6bcb-7017-4d94-9988-bc6a96b5b174
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-08 | |||||
| タイトル | ||||||
| タイトル | Activation of Antioxidative Enzymes Induced by Low-Dose-Rate Whole-Body Gamma Irradiation: Adaptive Response in Terms of Initial DNA Damage | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Otsuka, Kensuke
× Otsuka, Kensuke× Sakai, Kazuo× et.al× 酒井 一夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An adaptive response induced by long-term low-dose-rate irradiation in mice was evaluated in terms of the amount of DNA damage in the spleen analyzed by a comet assay. C57BL/ 6N female mice were irradiated with 0.5 Gy of 137Cs gamma rays at 1.2 mGy/h; thereafter, a challenge dose (0.4, 0.8 or 1.6 Gy) at a high dose rate was given. Less DNA damage was observed in the spleen cells of preirradiated mice than in those of mice that received the challenge dose only; an adaptive response in terms of DNA damage was induced by long-term low-dose-rate irradiation in mice. The gene expression of catalase and Mn-SOD was significantly increased in the spleen after 23 days of the low-dose-rate radiation (0.5 Gy). In addition, the enzymatic activity of catalase corresponded to the gene expression level; the increase in the activity was observed at day 23 (0.5 Gy). These results suggested that an enhancement of the antioxidative capacities played an important role in the reduction of initial DNA damage by low-dose-rate radiation. | |||||
| 書誌情報 |
Radiation Research 巻 166, 号 3, p. 474-478, 発行日 2006-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
