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LET dependence of the formation of oxidative damage 8-hydroxy-2'-deoxyguanosine(8-OHdG)in 2'-deoxyguanosine aqueous solution irradiated with heavy ions
https://repo.qst.go.jp/records/45653
https://repo.qst.go.jp/records/45653e1ca458b-3338-498b-903f-e69bcf1c175c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-29 | |||||
| タイトル | ||||||
| タイトル | LET dependence of the formation of oxidative damage 8-hydroxy-2'-deoxyguanosine(8-OHdG)in 2'-deoxyguanosine aqueous solution irradiated with heavy ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Furusawa, Yoshiya× Murayama, Chieko× Kusano, Yohsuke× Ito, Atsushi× 平山 亮一× 古澤 佳也× 村山 千恵子× 伊藤 敦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate the contribution of indirect action mediated by OH radicals in biological effects of high LET radiations, we examined the production of 8-hydroxy-20-deoxyguanosine (8-OHdG) in 20-deoxyguanosine aqueous solution using various ion species with an LET range from 20 to 300 keV/mm. The 8-OHdG yield decreased with increasing LET. In the hypoxic irradiation condition, the yield showed constant or rather increasing tendency above about 100 keV/mm, which is consistent with an oxygen-in-the-track hypothesis to explain the diminishment of oxygen effect. | |||||
| 書誌情報 |
Radiation Physics and Chemistry 巻 78, 号 12, p. 1207-1210, 発行日 2009-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-806X | |||||
