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Intracellular and extracellular redox environments surrounding redox-sensitive contrast agents under oxidative atmosphere
https://repo.qst.go.jp/records/45649
https://repo.qst.go.jp/records/456492655d83d-50b9-44ad-a220-ff1b04c93233
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-15 | |||||
| タイトル | ||||||
| タイトル | Intracellular and extracellular redox environments surrounding redox-sensitive contrast agents under oxidative atmosphere | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okajo, Aya
× Okajo, Aya× Ui, Iori× Manda, Sushma× Nakanishi, Ikuo× Matsumoto, Kenichiro× Anzai, Kazunori× Endo, Kazutoyo× Sushma, Manda× Ikuo, Nakanishi× Kenichiro, Matsumoto× Kazunori, Anzai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In vivo redox reactions of nitroxyl contrast agents in bile and blood under an oxidative atmosphere were investigated using normal healthy Wistar rats. Differences in intracellular and extracellular volumes in redox environments are discussed. Pharmacokinetic profiles of two nitroxyl contrast agents, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (carbamoyl-PROXYL), 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL), in bile and blood were monitored by an electron paramagnetic resonance spectrometer when the rat was breathing 100% O2 or was subcutaneously administrated 0.2 mmol/kg body weight of ferric citrate. Re-oxidation of hydroxylamines to nitroxyl radicals was caused in bile under 100% O2 breathing, but not in blood. The administration of ferric citrate caused marked re-oxidation in bile, but a slight reduction in blood. Tissue H2O2 level may partly play a role in the intracellular re-oxidation process. Tissue Fe3+ concentration can work more effectively for the intracellular re-oxidation of hydroxylamines. The intracellular environment is susceptible to oxidation compared with the extracellular environment under conditions such as 100% O2 breathing or iron overload. | |||||
| 書誌情報 |
Biological & Pharmaceutical Bulletin 巻 32, 号 4, p. 535-541, 発行日 2009-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
