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Effect of cyclooxygenase-2 on the regulation of cerebral blood flow during neuronal activation in the rat.
https://repo.qst.go.jp/records/45635
https://repo.qst.go.jp/records/4563533f48a38-8511-4fb0-866d-8d4b68dd9f62
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-14 | |||||
| タイトル | ||||||
| タイトル | Effect of cyclooxygenase-2 on the regulation of cerebral blood flow during neuronal activation in the rat. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsuura, Tetsuya
× Matsuura, Tetsuya× Takuwa, Hiroyuki× Bakalova-Zheleva, Rumiana× Obata, Takayuki× Kanno, Iwao× 松浦 哲也× 田桑 弘之× バカロバ ルミアナ× 小畠 隆行× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study was designed to clarify the precision of the main approach for investigating the regulation of local cerebral blood flow (CBF) response to neuronal activation in the brain (neurovascular coupling). In this study, we examined the effects of NS-398, a highly selective cyclooxygenase-2 inhibitor, on the physiological variables, baseline CBF, and local CBF response during rat somatosensory neuronal activation by laser-Doppler flowmetry. Blood pressure and heart rate were significantly decreased 3h after i.v. infusion of NS-398. Baseline CBF and local CBF during somatosensory activation gradually decreased with an increase in time of NS-398 infusion up to 3h, although neuronal activity in the somatosensory area was almost constant during the infusion. The results suggest that cyclooxygenase-2 participates in the regulation of local CBF during neuronal activation in rats. The present study also revealed the potential side-effects of dimethylsulfoxide, a solvent of NS-398, on neurovascular coupling. | |||||
| 書誌情報 |
Neuroscience Research 巻 65, 号 1, p. 64-70, 発行日 2009-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0168-0102 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.neures.2009.05.006 | |||||
