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Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen
https://repo.qst.go.jp/records/45634
https://repo.qst.go.jp/records/45634a7d3db55-4bb7-48e1-8e1d-a4dcef0e28a2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-14 | |||||
| タイトル | ||||||
| タイトル | Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Miyamoto, Tadaaki
× Miyamoto, Tadaaki× Baba, Masayuki× Yamamoto, Naoyoshi× Koto, Masashi× Sugawara, Toshiyuki× Yashiro, Tomoyasu× Kadono, Kennosuke× Ezawa, Hidefumi× Tsujii, Hirohiko× Mizoe, Junetsu× Yoshikawa, Kyosan× Kandatsu, Susumu× Fujisawa, Takehiko× 宮本 忠昭× 馬場 雅行× 山本 直敬× 小藤 昌志× 菅原 俊幸× 矢代 智康× 上遠野 賢之助× 江澤 英史× 辻井 博彦× 溝江 純悦× 吉川 京燦× 神立 進× 藤澤 武彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: A phase I/II study on carbon ion radiotherapy for stage I non-small cell lung cancer (NSCLC) was first conducted from 1994 to 1999 and determined the optimal dose. Second, a phase II study using the optimal dose was performed. The purpose of the present study was to clarify the local control and 5-year survival rates. Methods and Materials: From April 1999 to December 2000, 50 patients with 51 primary lesions were treated. Using a fixed dose of 72GyE in 9 fractions over 3 weeks, the primary tumors were irradiated with carbon ion beams alone. The average age of the patients was 74.5 years. Thirty three (66%) of them were medically inoperable. Local control and survival were determined by using the Kaplan-Meier method and the data were statistically processed by using the long-rank test. Results: All patients were observed for a minimum of 5 years or until death with a median follow-up time of 59.2 months ranging from 6.0 months to 83.0 months. The local control rate for all patients was 94.7%. The patients five-year cause-specific survival rate was 75.7% (IA: 89.4 IB: 55.1), and overall survival 50.0% (IA: 55.2, IB: 42.9). No toxic reactions in the lung greater than grade 3 were detected. Conclusions: Carbon ion radiotherapy, a new treatment modality with superior benefits in terms of QOL and ADL, has been proven as a valid alternative to surgery for stage I NSCLC and to offer particular benefits especially for elderly and inoperable patients. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 67, 号 3, p. 750-758, 発行日 2007-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ijrobp.2006.10.006 | |||||
