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A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution
https://repo.qst.go.jp/records/45628
https://repo.qst.go.jp/records/4562874a5ee68-edde-40c9-b27f-c485fdddf38c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-04 | |||||
| タイトル | ||||||
| タイトル | A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasegawa, Sumitaka
× Hasegawa, Sumitaka× Maruyama, Kouichi× Takenaka, Hikaru× Furukawa, Takako× Saga, Tsuneo× 長谷川 純崇× 丸山 耕一× 竹中 光× 古川 高子× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The recent success with small fish as an animal model of cancer with the aid of fluorescence technique has attracted cancer modelers' attention because it would be possible to directly visualize tumor cells in vivo in real time. Here, we report a medaka model capable of allowing the observation of various cell behaviors of transplanted tumor cells, such as cell proliferation and metastasis, which were visualized easily in vivo. We established medaka melanoma (MM) cells stably expressing GFP and transplanted them into nonirradiated and irradiated medaka. The tumor cells were grown at the injection sites in medaka, and the spatiotemporal changes were visualized under a fluorescence stereoscopic microscope at a cellular-level resolution, and even at a single-cell level. Tumor dormancy and metastasis were also observed. Interestingly, in irradiated medaka, accelerated tumor growth and metastasis of the transplanted tumor cells were directly visualized. Our medaka model provides an opportunity to visualize in vivo tumor cells "as seen in a culture dish" and would be useful for in vivo tumor cell biology. | |||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America 巻 106, 号 33, p. 13832-13837, 発行日 2009-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0027-8424 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1073/pnas.0903999106 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | www.pnas.org/cgi/doi/10.1073/pnas.0903999106 | |||||
| 関連名称 | www.pnas.org/cgi/doi/10.1073/pnas.0903999106 | |||||
