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Radiobiologic significance of the response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with gamma-rays and reactor neutron beams
https://repo.qst.go.jp/records/45622
https://repo.qst.go.jp/records/45622b27f26cf-9bca-48ba-9319-bc54ceb86126
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-08-27 | |||||
| タイトル | ||||||
| タイトル | Radiobiologic significance of the response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with gamma-rays and reactor neutron beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Masunaga, Shinichiro
× Masunaga, Shinichiro× Ando, Koichi× Uzawa, Akiko× Hirayama, Ryoichi× Furusawa, Yoshiya× Koike, Sachiko× et.al× 増永 慎一郎× 安藤 興一× 鵜澤 玲子× 平山 亮一× 古澤 佳也× 小池 幸子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To clarify the radiosensitivity of intratumor quiescent cells in vivo to accelerated carbon ion beams and reactor neutron beams. Methods and Materials: Squamous cell carcinoma VII tumor-bearing mice were continuously given 5-bromo-20-deoxyuridine to label all intratumor proliferating cells. Next, they received accelerated carbon ion or g-ray high-dose-rate (HDR) or reduced-dose-rate (RDR) irradiation. Other tumor-bearing mice received reactor thermal or epithermal neutrons with RDR irradiation. Immediately after HDR and RDR irradiation or 12 h after HDR irradiation, the response of quiescent cells was assessed in terms of the micronucleus frequency using immunofluorescence staining for 5-bromo-20-deoxyuridine. The response of the total (proliferating plus quiescent) tumor cells was determined from the 5-bromo-20-deoxyuridine nontreated tumors. Results: The difference in radiosensitivity between the total and quiescent cell populations after g-ray irradiation was markedly reduced with reactor neutron beams or accelerated carbon ion beams, especially with a greater linear energy transfer (LET) value. Clearer repair in quiescent cells than in total cells through delayed assay or a decrease in the dose rate with g-ray irradiation was efficiently inhibited with carbon ion beams, especially with a greater LET. With RDR irradiation, the radiosensitivity to accelerated carbon ion beams with a greater LET was almost similar to that to reactor thermal and epithermal neutron beams. Conclusion: In terms of tumor cell-killing effect as a whole, including quiescent cells, accelerated carbon ion beams, especially with greater LET values, are very useful for suppressing the dependency on the heterogeneity within solid tumors, as well as depositing the radiation dose precisely. |
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| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 70, 号 1, p. 221-228, 発行日 2008-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
