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Utility decay rates of T1-weighted magnetic resonance imaging contrast based on redox-sensitive paramagnetic nitroxyl contrast agents
https://repo.qst.go.jp/records/45480
https://repo.qst.go.jp/records/45480eb968993-c942-4a6b-9b93-626969eeb84d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-15 | |||||
| タイトル | ||||||
| タイトル | Utility decay rates of T1-weighted magnetic resonance imaging contrast based on redox-sensitive paramagnetic nitroxyl contrast agents | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Kenichiro
× Matsumoto, Kenichiro× Kenichiro, Matsumoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The availability and applicability of the combination of paramagnetic nitroxyl contrast agent and T1-weighted gradient echo (GE)-based dynamic magnetic resonance imaging (MRI) measurement for redox imaging are described. The time courses of T1-weighted GE MRI signal intensities according to first-order paramagnetic loss of a nitroxyl contrast agent were simulated for several experimental conditions. The apparent decay rate calculated based on decreasing T1-weighted MRI contrast (kMRI) can show an approximate value of the original decay rate (ktrue) discretionarily given for simulation with suitable experimental parameters. The difference between kMRI and ktrue can be sufficiently small under T1-weighted spoiled gradient echo (SPGR) scan conditions (repetition time = 75 ms, echo time = 3 ms, and flip angle = 45 deg), with a conventional redox-sensitive nitroxyl contrast agent, such as 4-hydroxy-2,2,6,6,-tetramethylpiperidine-N-oxyl (TEMPOL) and/or 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (carbamoyl-PROXYL), and with i.v. doses of below 1.5m mol/g b.w. for mice. The results of this simulation suggest that the kMRI of nitroxyl contrast agents can be the primary index of redox status under biological conditions. | |||||
| 書誌情報 |
Biological & Pharmaceutical Bulletin 巻 32, 号 4, p. 711-716, 発行日 2009-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
